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tag mitotic spindle disease medicine

How huntingtin kills neurons?
Jennifer Welsh | Aug 10, 2010 | 3 min read
Researchers have revealed new clues to how a defective form of the huntingtin protein may cause the deadly changes that lead to Huntington's disease -- by potentially disrupting the process of neurogenesis, thereby decreasing neural progenitor cells. Huntingtin proteinImage: Wikimedia commons, Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute"[This is] the first study to demonstrate that normal huntingtin has fundamental developmental roles in mitotic spindle function
The Philadelphia Chromosome, circa 1960
Cristina Luiggi | Dec 1, 2010 | 2 min read
By Cristina Luiggi The Philadelphia Chromosome, circa 1960 Related Articles New Smoking Gun? Cancer Genetics Gets Personal New Medicine Means Research RethinkLess than a decade after Watson and Crick published their landmark paper on the structure of DNA, two Philadelphia researchers noticed that the blood cells of patients with chronic myelogenous leukemia (CML) had an unusually tiny chromosome. At a time when the genetic underpinnings of disease were unc
Conceptual image showing fragmented X chromosomes
How Chaos in Chromosomes Helps Drive Cancer Spread
Samuel F. Bakhoum | Mar 1, 2022 | 10+ min read
A new link between inflammation and rampant chromosomal abnormalities reveals novel strategies to treat diverse malignancies.
Mapping Brain Proteins
Devika G. Bansal | Feb 1, 2018 | 7 min read
Researchers are using souped-up mass spectrometry to localize proteins within brain cells.
One Man's Trash...
Kerry Grens | Dec 1, 2013 | 10+ min read
Scientists who dared to waste their time looking at the midbody, a remnant of cell division, have catapulted the organelle to new prominence.
Appraising Aneuploidy as a Cancer Cause
Douglas Steinberg | Mar 14, 2004 | 6 min read
THE TRIPLETS OF CELLVILLE:(Reprinted with permission from G.A. Pihan et al., Cancer Res, 63: 1398–404, 2003)When stained with a biotinylated probe specific for the chromosome 8 centromere, diploid cells from normal human uterine cervix (A), breast (C), and prostate (E) tissue show two signals. Aneuploid cells from carcinoma tissues in situ (B, D, and F) each have three or more signals.About 70 scientists recently attended an invitation-only California premiere tinged with controversy. But
Freeze Frame
Jeffrey M. Perkel | Feb 1, 2009 | 10 min read
How to troubleshoot sample preparation for cryo-electron microscopy, an up-and-coming structural biology technique.

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