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image: Anti-CRISPR Protein Reduces Off-Target Effects

Anti-CRISPR Protein Reduces Off-Target Effects

By | July 12, 2017

AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.

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image: Cell Cannibalism as Cancer Defense

Cell Cannibalism as Cancer Defense

By | July 11, 2017

A new study suggests that the mysterious process by which one cell consumes another may be triggered by cell division, potentially helping to fight tumor growth.

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image: RNA Protects “Naked” Genomes from Retrotransposons

RNA Protects “Naked” Genomes from Retrotransposons

By | June 30, 2017

Transfer RNA fragments prevent jumping genes from hopping around in the mouse embryo, when histone methylation can’t do the job.

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Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.

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image: Transgenic Mouse Illuminates Melanoma Metastasis

Transgenic Mouse Illuminates Melanoma Metastasis

By | June 28, 2017

Glowing cells mark the routes of tumor spread by way of newly formed lymph vessels. 

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The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts.  

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image: Cancer Studies Seem Replicable

Cancer Studies Seem Replicable

By | June 27, 2017

In the latest findings from the Reproducibility Project: Cancer Biology, independent researchers achieve results that mirror those of two earlier papers.

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The International Mouse Phenotyping Consortium aims to characterize the entire mouse genome, starting first with more than 3,300 genes. 

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An analysis of human cancer genome projects uncovers a counterintuitive loss of ribosomal gene copies.

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image: Gut Feeling

Gut Feeling

By | June 22, 2017

Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

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