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tag transcriptional regulation cell molecular biology immunology ecology

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Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Molecular Biology
The Scientist Staff | Sep 1, 1991 | 1 min read
S. Ghosh, D. Baltimore, "Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB," Nature, 344:678-82, 1990. Sankar Ghosh (Whitehead Institute for Biomedical Research, Cambridge, Mass.): "This paper brings together two areas of rapidly moving research: the role of protein phosphorylation and control of transcriptional regulation. The inhibitor IkB not only keeps the transcription factor NF-kB in the cytoplasm--away from DNA--but also directly prevents it from binding to DNA. By sh
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Immunology
The Scientist Staff | Feb 3, 1991 | 1 min read
J.J. Siekierka, S.H.Y. Hung, M. Poe, C.S. Lin, N.H. Sigal, "A cytosolic binding protein for the immunosuppressant FK-506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin," Nature, 341, 755-7, 26 October 1989. John J. Siekierka (Merck Sharp & Dohme Research Laboratories, Rahway, N.J.): "Two clinically important immunosuppressant drugs, cyclosporin A (CsA) and FK-506, are valuable probes for studying the molecular mechanisms of T cell activation. Although chemically uniqu
Top 7 in Molecular Biology
Tia Ghose | Nov 1, 2011 | 3 min read
A snapshot of the most highly ranked articles in molecular biology and related areas, from Faculty of 1000
Transcription factors link rhizobia, legumes
Ishani Ganguli(iganguli@the-scientist.com) | Jun 19, 2005 | 3 min read
GRAS family proteins found to regulate nodules where nitrogen-fixing bacteria live
Immunology: Highlights From A Hot Biological Field
Scott Veggeberg | Mar 21, 1993 | 6 min read
Some of the most influential papers in 1992, according to data provided by the Philadelphia-based Institute for Scientific Information, were in immunology. This is not surprising, given the field's applications in stemming AIDS, cancer, and other pressing diseases. The most cited paper published within the last two years is from the Max Planck Institute for Biology in Tbingen, Germany (K. Falk, et al., Nature, 351:290, 1991). This paper, which by the end of February 1993 had been referred to i
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
3d rendered medically accurate illustration of a human embryo anatomy
The Ephemeral Life of the Placenta
Danielle Gerhard, PhD | Dec 4, 2023 | 10+ min read
Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.

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