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tag telomerase

Telomerase
The Scientist Staff | Oct 10, 1999 | 6 min read
Edited by: Paul Smaglik Thomas R. Cech T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.R. Cech, "Telomerase catalytic subunit homologs from fission yeast and human," Science, 277:955-9, Aug. 15, 1997. (Cited in more than 220 papers since publication) Comments by Thomas R. Cech, professor of biochemistry, biophysics, and genetics at the University of Colorado Health Sciences Center, Boulder This paper is "a derivative," laughs Thomas Cech. The
Of Cells and Limits
Anna Azvolinsky | Mar 1, 2015 | 9 min read
Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement.
New clue to how telomeres work
Jef Akst | Mar 24, 2010 | 3 min read
One protein appears to play an integral role in protecting telomeres, and possibly preventing cancerous growth, according to a study published this week in Science. Chromosomes with fluorescently tagged telomeres in cells that lack Rap1and Ku. The arrows point to examples of telomere-sister chromatid exchanges.Image: Titia de Lange laboratoryThe protein in question is part of a complex called shelterin, which prevents a potentially dangerous type of DNA repair that can shorten telomeres and
A Vaulted Mystery
Eufemia S. Putortì and Massimo P. Crippa | Aug 1, 2014 | 10+ min read
Nearly 30 years after the discovery of tiny barrel-shape structures called vaults, their natural functions remain elusive. Nevertheless, researchers are beginning to put these nanoparticles to work in biomedicine.
New Smoking Gun?
Jef Akst | Apr 1, 2010 | 4 min read
By Jef Akst New Smoking Gun? Teams come together to target the genes behind lung cancer, but the hunt is far from over. Image modified from © Alfred Pasieka / Photo Researchers, Inc. Scientists have known for years why more than 1 million people die of lung cancer every year—smoking. Thus, when it came to looking for a genetic basis to lung cancer, “there was a lot of skepticism” about the importance of such rese
Research Notes
Eugene Russo | Jun 25, 2000 | 5 min read
Putting Polio to Good Use Add polio to a host of other viral and bacterial foes that, in modified forms, could prove therapeutically beneficial. Although Russian scientists attempted to use polio to treat cancer in the 1960s--unpublished experiments about which little is known--a recent brain cancer study in mice is the first modern-day attempt to harness the power of the virus (M. Gromeier et al., "Intergeneric poliovirus recombinants for the treatment of malignant glioma," Proceedings of the
How to Create a Successful Fish Tale?
A. J. S. Rayl | Aug 19, 2001 | 10+ min read
More than 80 percent of the planet's living organisms exist only in aquatic ecosystems. Some may harbor secrets to human origins, and clues, treatments--perhaps even cures--for human disease. Some are critical bioindicators that portend the health of the biosphere. Yet, overall, scientists know little about the biochemical processes of these life forms. The vast, rich knowledge within the oceans and freshwater systems on Earth remains virtually untapped, because in the world of biological resear

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