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Nerve cell labelled with different colours
Psychedelics Slip Past Cell Membranes When Treating Depression
The antidepressant properties of hallucinogenic drugs may stem from their ability to bind to intracellular serotonin receptors, a study suggests.
Psychedelics Slip Past Cell Membranes When Treating Depression
Psychedelics Slip Past Cell Membranes When Treating Depression

The antidepressant properties of hallucinogenic drugs may stem from their ability to bind to intracellular serotonin receptors, a study suggests.

The antidepressant properties of hallucinogenic drugs may stem from their ability to bind to intracellular serotonin receptors, a study suggests.

antidepressants

magic mushrooms on a while background
Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial
Shawna Williams | Nov 3, 2022 | 2 min read
The research has caveats, including side effects and a lack of durability in the benefits of a single dose.
blue-gloved hands injecting mouse with syringe
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
Shawna Williams | Sep 8, 2022 | 3 min read
The findings likely have implications for animal research far beyond the study of antidepressants.
Molecular structure of fluvoxamine
A Closer Look at the New Fluvoxamine Trial Data
Catherine Offord | Nov 2, 2021 | 8 min read
Authors of a newly published study on the use of an antidepressant for COVID-19 claim the drug greatly reduces hospitalizations and mortality. But some experts question whether that’s really what the data show.
a brain surrounded by pills
Years of Prozac Alter Lipids in Young Monkeys’ Brains: Study
James M. Gaines | Sep 10, 2021 | 4 min read
Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.
Deep Brain Stimulation Improves Depression Symptoms: Study
Catherine Offord | Oct 7, 2019 | 2 min read
The effects of the therapy in a small group of  patients were long-lasting, researchers say, adding to evidence that the approach works for treatment-resistant depression.
Rabbit Study May Hint at Origin of Female Orgasm in Humans
Catherine Offord | Oct 1, 2019 | 2 min read
It could be a throwback to a mechanism that induces ovulation during sex, researchers propose, but not everyone thinks the results can be extrapolated to people.
Antidepressant Approvals Could Herald New Era in Psychiatric Drugs
Bianca Nogrady | Oct 1, 2019 | 9 min read
The FDA has given the green light to the first major new classes of antidepressant therapies in decades, opening up new avenues for therapeutic development.
Forced-Swim Test Criticized as Uninformative, Cruel
Catherine Offord | Jul 22, 2019 | 2 min read
Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.
How the Brain Changes on Ketamine: A Live Animal Study
Ruth Williams | Apr 11, 2019 | 3 min read
The drug promotes and sustains brain cell connectivity in mice, reversing the effects of chronic stress.
Esketamine, a Treatment for Depression, Receives FDA Approval
Carolyn Wilke | Mar 6, 2019 | 2 min read
The nasal spray to ease intractable depression appears on the US market after decades without novel antidepressant treatments.
Effects of Antidepressants Span Three Generations in Fish
Diana Kwon | Dec 10, 2018 | 4 min read
Fluoxetine dampened stress responses in zebrafish embryos exposed to the drug—and their descendants.
Experimental Drug Relieves Blast-Related PTSD in a Rat Model of Traumatic Brain Injury
Viviane Callier | Feb 1, 2018 | 4 min read
The compound, BCI-838, is already in human clinical trials as a possible treatment for depression.
Neurometabolic Disorders Could Contribute to Depression
Ben Andrew Henry | Nov 1, 2016 | 3 min read
Impairments in the production of neurotransmitters may lead to depression in some patients, preliminary results show, opening new avenues for research.
Hot Off the Presses
Bob Grant | Jun 1, 2016 | 3 min read
Beyond Biocentrism, The Sting of the Wild, The Birth of Anthropocene, and Ordinarily Well
Zooming In on an Antidepressant Target
Ruth Williams | Apr 6, 2016 | 3 min read
Structural studies reveal how SSRI drugs bind to the human serotonin transporter.
Antidepressant Exerts Epigenetic Changes
Anna Azvolinsky | Nov 25, 2015 | 3 min read
Molecular markers could aid researchers’ assessment of patient response to the drug.
 
Antidepressant Could Be Prophylactic for Alzheimer’s
Rina Shaikh-Lesko | May 14, 2014 | 3 min read
An SSRI commonly prescribed to treat depression could help prevent the formation of Alzheimer’s disease-associated amyloid plaques.
Ketamine Alternative Shows Promise
Abby Olena, PhD | Oct 16, 2013 | 2 min read
Researchers show that lanicemine is an effective antidepressant without the adverse effects of the related hallucinogenic drug.
Natural Antidepressant Discovered
Sabrina Richards | Jun 25, 2012 | 3 min read
A newly recognized chemical factor in the brain, called neuritin, regulates plasticity and may play a role in depression.
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