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tag transition state enzyme inhibitors microbiology

bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Small Molecules in Large Proteins
Nadia Halim | Aug 20, 2000 | 9 min read
A theme is emerging in antiangiogenesis research: Small molecules stored within large proteins in the body can stop cancer cells from creating new blood vessels. Many enzymes that a tumor uses to invade surrounding tissue generate these angiogenesis inhibitors, but a tumor can locally override the effect of the inhibitors by generating angiogenesis stimulators. If researchers could shift this balance by increasing the concentration of endogenous angiogenesis inhibitors, they could potentially ar
Bacteria Harbor Geometric “Organelles”
Amber Dance | Dec 1, 2018 | 10+ min read
Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.
Decoding DNA: New Twists and Turns
Kerry Grens | Jun 1, 2013 | 10+ min read
Highlights from a series of three webinars on the future of genome research, held by The Scientist to celebrate 60 years of the DNA double helix
Enzymology's New Frontiers
Mark Greener(biowriter@markgreener.fsnet.co.uk) | Jan 18, 2004 | 10+ min read
Investigators are learning about structures and rethinking old theories
Chloroplast Studies Point to Crop Enhancements
Barry Palevitz | Apr 11, 1999 | 5 min read
With news about Dolly and embryonic stem cells the stuff of cocktail party conversation, cloning a transgenic sheep or cow seems like child's play. The recipe is simple: Insert a pet gene into the nucleus of a cultured cell, fuse it with an enucleated egg, and voilà--a cow with high-octane milk. But incorporating genes into nuclear chromosomes isn't the only road to fame and fortune. Animals and plants have other sources of genetic information--their respiratory mitochondria and photosy
AIDS Investigators Cautiously Applauding Recent Advances
Steven Benowitz | Sep 29, 1996 | 10+ min read
Discoveries announced at conference leave scientists feeling optimistic; yet their enthusiasm is tempered by several persistent concerns. AIDS researchers have many reasons to be encouraged. Studies show that treatments combining new and old drugs can control HIV levels in the blood. Moreover, many scientists and activists note, prevention efforts have helped reduce HIV infection rates. Yet the enthusiasm is tempered by several caveats. Drugs are expensive and have harsh side effects, leading
Systems Biology: Beyond the Buzz
H. Steven Wiley | Jun 1, 2006 | 10 min read
FEATURESystems Biology © THOM GRAVES Lessons from EGFR research show how to kick-start a systems approach for other areas of biology BY H. STEVEN WILEYARTICLE EXTRASInfographic: Seeing EGFR from a Systems PerspectiveIf you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even
Flow Cytometry: It's Not Just For Immunologists Anymore
James Kling | Jun 22, 1997 | 9 min read
A low-profile child of the '60s, flow cytometry didn't capture the imagination of most researchers until the early 1980s. The decade saw the birth of the AIDS epidemic, and as attention focused on HIV, researchers needed a method to accurately and reproducibly characterize immune cells. Flow cytometry was suddenly thrust into the spotlight. COMPLETE KITS: Bio-Rad’s KINESIS reagent kits for flow cytometry assays A flow cytometer shines one or more lasers on a sample of cells in suspension

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