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tag telomere evolution disease medicine

Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Telomere Findings May Yield Tips For Treating Cancer, Geriatric Disorders
Ricki Lewis | Feb 18, 1996 | 7 min read
Geriatric Disorders Author: Ricki Lewis SIDEBAR : TELOMERE BIOLOGY RESOURCES Chromosome tips, called telomeres, have long fascinated geneticists because they protect chromosomes from degradation. And recent research has revealed another vital role for telomeres: As they shrink with each cell division, they keep a biochemical tally of the number of divisions remaining in a cell's lifetime. If this precise control goes awry, the biochemical consequences could be dire, such as uncontrolled growt
Control ALT, Delete Cancer
Haroldo Silva, David Halvorsen, and Jeremy D. Henson | Apr 1, 2015 | 5 min read
Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020 | 10+ min read
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Week in Review: November 11–15
Tracy Vence | Nov 15, 2013 | 3 min read
Combating bacterial persistence; ancient canine evolution; T cells and transplants; sharing omics data and code
Week in Review: June 16–20
Tracy Vence | Jun 20, 2014 | 2 min read
Early Neanderthal evolution; developing antivirals to combat polio; the mouth and skin microbiomes; insect-inspired, flight-stabilizing sensors
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Conceptual image showing fragmented X chromosomes
How Chaos in Chromosomes Helps Drive Cancer Spread
Samuel F. Bakhoum | Mar 1, 2022 | 10+ min read
A new link between inflammation and rampant chromosomal abnormalities reveals novel strategies to treat diverse malignancies.

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