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tag single nucleotide polymorphism cell molecular biology ecology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Eytan Stibbe wears a headset and a blue shirt while surrounded by computers and other equipment on the International Space Station.
Whenever, Wherever: Taking DNA Amplification Outside the Lab
Hannah Thomasy, PhD | Dec 4, 2023 | 10 min read
Recombinase polymerase amplification lets researchers rapidly replicate DNA in the clinic, in the field, or even in the International Space Station.
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | Nov 14, 2023 | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Epithelial cells and fungal spores are marked with fluorescent dyes. Cells have an irregular shape and are shown in green and blue colors. Spores are spherical in shape and are labeled green if they are surrounded by p11 protein. A protein in mature phagosomes is labeled violet.
Fungal Spores Hijack a Host Protein to Escape Death
Mariella Bodemeier Loayza Careaga, PhD | Jun 20, 2023 | 3 min read
Uncovering the components used by Aspergillus fumigatus to avoid intracellular destruction broadens our understanding of the mold’s pathogenesis. 
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Whole-Genome SNP Genotyping
Marilee Ogren | Jun 1, 2003 | 8 min read
Clockwise from top left: images courtesy of Affymetrix, Illumina, Sequenom and Illumina Take any two individuals, sequence and compare their genomic DNA, and you'll find that the vast majority (about 99.9%) of the sequences are identical. In the remaining 0.1% lie differences in disease susceptibility, environmental response, and drug metabolism. Researchers are understandably keen to dissect these variations, most of which take the form of single-nucleotide polymorphisms (SNPs). A SNP (pron
Building Nanoscale Structures with DNA
Arun Richard Chandrasekaran | Jul 16, 2017 | 10+ min read
The versatility of geometric shapes made from the nucleic acid are proving useful in a wide variety of fields from molecular computation to biology to medicine.

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