Jonathan Weitzman(jonathanweitzman@hotmail.com) | Jun 5, 2001 | 1 min read
SNPs (single nucleotide polymorphisms) are valuable markers for mapping mutations and human disease-related genes. In the June issue of Nature Genetics, Wicks et al. describe a SNP-based strategy for rapid mapping in the C. elegans genome (Nature Genetics 2001, 28:160-164). They sequenced the entire genome of the CB4856 Hawaiian worm isolate and compared it with the standard laboratory wild type strain (Bristol N2). This alignment identified 6,222 potential polymorphisms, more than half of which