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tag kidney stone genetics genomics

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
3d rendered medically accurate illustration of a human embryo anatomy
The Ephemeral Life of the Placenta
Danielle Gerhard, PhD | Dec 4, 2023 | 10+ min read
Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.
Toward a “Clickable Plant”
Jane Salodof Macneil | Feb 15, 2004 | 9 min read
By conscious design, plant genomics initiatives have devoted initial resources to new technology development. Part of that money went to developing functional genomics approaches, and part to new sequencing technologies.
Pufferfish Genomes Probe Human Genes
Ricki Lewis | Mar 17, 2002 | 7 min read
It may be humbling to think that humans have much in common with pufferfish, but at the genome level, the two are practically kissing cousins. "In terms of gene complement, we are at least 90% similar—probably higher. There are big differences in gene expression levels and alternate transcripts, but if you're talking about diversity, number and types of proteins, then it's pretty difficult to tell us apart," says Greg Elgar, group leader of the Fugu genome project at the Medical Research C
Software Helps Researchers In Sorting Through The Human Genome
Ricki Lewis | Jul 21, 1996 | 10 min read
The Human Genome SIDEBAR : Selected Suppliers of Software for Gene Discovery and Analysis Genetics has been an informational science since the elucidation of DNA's structure. Today's researchers say the field shifted to a more computational mode in 1990-the year that research groups began mapping genes to specific chromosomal sites for the Human Genome Project. "That year was pivotal, because it was then that the need to sequence significant amounts of DNA became compelling," says Richard Gib
Yeast Proteomics Milestone
Aileen Constans | Dec 14, 2003 | 4 min read
Courtesy of Won-Ki Huh  LOCAL COLOR: Researchers used librar-ies of tagged proteins to determine where those proteins accumulate, and to what levels. Shown are representative localization (top) and co-localization (bottom) data. Researchers from the University of California, San Francisco, have probed the yeast proteome in the highest level of detail to date. Using sets of fusion-tagged proteins, the scientists, led by Howard Hughes Medical Institute investigators Erin O'Shea and Jonatha
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Reductio Ad Amino Acid
Bob Sinclair | Feb 1, 1999 | 10+ min read
Date: February 1, 1999Fusion/Tag Proteases TableProteolytic Enzymes TableTable 3Table 4 A proteome analysis aims to characterize all proteins expressed by an organism or tissue. The next step will be to correlate a protein profile with the appropriate genome, and beyond that researchers will want to understand the correlations between levels of proteins, co- and post-translational modifications, and cell or tissue activity. Many of the technologies that are necessary to realize this goal are de

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