schizophrenia, genetics & genomics, neuroscience

Brain banks have struggled to convince unaffected individuals to donate, hampering studies on “cognitively normal” neurodevelopment and aging.

The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.

Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression. 

Genetic evidence suggests that overactive synaptic pruning drives development of schizophrenia.

Researchers link disease-associated mutations to excitatory and inhibitory signaling in the brain.

A study that identified genes linked to communication between different areas of the brain has been retracted by its authors because of statistical flaws. 

Two studies provide insight into the genetics of the disorder and show again how complex it is.

Innovations in imaging techniques and genetic sequencing take neuroscience to a new level.

Researchers are piecing together the devilishly complex sets of genetic alterations underlying schizophrenia and bipolar disorder.