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tag tay sachs disease cell molecular biology microbiology

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Epithelial cells and fungal spores are marked with fluorescent dyes. Cells have an irregular shape and are shown in green and blue colors. Spores are spherical in shape and are labeled green if they are surrounded by p11 protein. A protein in mature phagosomes is labeled violet.
Fungal Spores Hijack a Host Protein to Escape Death
Mariella Bodemeier Loayza Careaga, PhD | Jun 20, 2023 | 3 min read
Uncovering the components used by Aspergillus fumigatus to avoid intracellular destruction broadens our understanding of the mold’s pathogenesis. 
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Of Cells and Limits
Anna Azvolinsky | Mar 1, 2015 | 9 min read
Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement.
The AIDS Research Evaluators
Lynn Gambale | Jul 9, 1995 | 6 min read
Chairman: Arnold Levine, chairman, department of molecular biology, Princeton University Barry Bloom, Weinstock Professor and Howard Hughes Medical Institute (HHMI) investigator, department of microbiology and immunology, Albert Einstein College of Medicine, New York Rebecca Buckley, professor of pediatrics and immunology, Duke University Medical Center Charles Carpenter, chairman, Office of AIDS Research Advisory Committee; professor of medicine,Brown University School of Medicine Don
Glycobiology Goes to the Ball
Jeffrey Perkel | Apr 28, 2002 | 8 min read
There's more to life than DNA, RNA, and proteins. Literally. Sugars are also in the mix. And the roles that carbohydrates play in biology are just as important as those of any member of the better-characterized trinity. These macromolecules affect cell-cell interactions, immune function, and protein regulation, and disruption of their biology results in disease. One magazine likened the study of carbohydrates, called glycobiology, to Cinderella—neglected stepsister to her two more glamoro
Picturing Infection
Kelly Rae Chi | Jan 1, 2015 | 7 min read
Whole-animal, light-based imaging of infected small mammals
Top Ten Innovations 2011
The Scientist | Jan 1, 2012 | 10+ min read
Our list of the best and brightest products that 2011 had to offer the life scientist
A Genetic Checkup: Lessons from Huntington Disease and Cystic Fibrosis
Ricki Lewis | Oct 19, 2003 | 9 min read
Thom Graves Media While genome sequencing may be the new kid on the block--perhaps now with a cracking voice and fuzzy facial hair--predicting phenotypes is the stuff of classical genetics, honed on the rare single-gene disorders, such as Huntington disease (HD) and cystic fibrosis (CF), which dominated the field in the last century (see Genetic Testing Timeline). "Geneticists today are portrayed as soothsayers of the future. But predictive medicine and testing has a significant history," says
Race and the Clinic: Good Science?
Ricki Lewis | Feb 17, 2002 | 8 min read
Humans have long embraced the idea of grouping and naming people who have distinct, genetically determined physical characteristics, like almond-shaped eyes or different skin color. It made sense, from a social standpoint (think safety, politics, and business) to align one's self with kin. However, studying race from a biological point of view, in the hopes of learning about specific diseases or developing new drugs, is a different matter altogether. "Race is generally not a useful consideration

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