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tag tay sachs disease developmental biology genetics genomics

On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
Founder Populations Fuel Gene Discovery
Ricki Lewis | Apr 15, 2001 | 8 min read
The field of human genetics has never been "politically correct." The first gene screens created in the 1970s, for sickle cell disease and Tay-Sachs disease, targeted African American and Ashkenazi (eastern European) Jewish populations, respectively. This targeting made economic sense as these conditions are more prevalent within these populations. It isn't that genes discriminate, but that the human tendency to select mates like themselves tends to keep particular gene variants within certain g
Genetics-Based Testing Could Create A Biologic Underclass
Dorothy Nelkin | Nov 26, 1989 | 9 min read
[Editor’s note: Sophisticated biological tests that can uncover latent problems or predict future diseases have been developed over the past few years. Such tests have important clinical applications, but they also have found their way into nonclinical contexts in which they provide unprecedented threats to our traditional concepts of privacy and personal autonomy. So say Dorothy Nelkin and Laurence Tancredi, coauthors of a new book, Dangerous Diagnostics: The Social Power of Biological I
Mini organs in a dish
What Are Organoids and How Are They Made?
Jennifer Zieba, PhD | Aug 11, 2022 | 8 min read
Miniaturized, in vitro versions of organs provide insights into disease and development.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
Preimplantation Genetic Diagnosis: The Next Big Thing?
Ricki Lewis | Nov 12, 2000 | 9 min read
Courtesy of David Hill, ART Reproductive Center Inc.Two separated blastomeres subjected to FISH analysis to check the chromosomes. In early October, preimplantation genetic diagnosis (PGD) made headlines when a Colorado couple used assisted reproductive technology (ART) to have a baby named Adam, whose umbilical cord stem cells could cure his six-year-old sister Molly's Fanconi anemia.1 When Adam Nash was a ball of blastomere cells, researchers at the Reproductive Genetics Institute at Illinois
CRISPR Can Track Cellular History of a Mammalian Embryo
Sukanya Charuchandra | Aug 10, 2018 | 2 min read
Researchers used the genome-editing technology to analyze the development of mouse tissues.
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat

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