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image: RNAi’s Future in Drug-Target Screening

RNAi’s Future in Drug-Target Screening

By | April 17, 2017

A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 

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image: CRISPR Corrects Duchenne-Causing Mutations

CRISPR Corrects Duchenne-Causing Mutations

By | April 12, 2017

Using CRISPR-Cpf1 gene editing, researchers have fixed mutations that cause a form of muscular dystrophy in cultured human cardiomyocytes and a mouse model.

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Scientists identify a mutation in the CRY1 gene in people with abnormal sleeping patterns.

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23andMe customers can now receive information about genetic risk for diseases including Parkinson’s and celiac.

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Octopus, cuttlefish, and squid extensively edit messenger RNAs in an evolutionarily conserved process. 

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image: Cross-Sample Sequencing Contamination Galore

Cross-Sample Sequencing Contamination Galore

By | April 5, 2017

Scientists conducting a large-scale, comparative transcriptomics project have inadvertently highlighted widespread contamination in sequencing data.

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image: Mutations Linked to Secondary Cancers

Mutations Linked to Secondary Cancers

By | April 4, 2017

Childhood cancer survivors with mutations in certain cancer-risk genes have a higher risk of developing additional neoplasms later in life, according to research presented at the American Association for Cancer Research annual meeting.

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At the annual American Association for Cancer Research meeting, researchers discuss the importance of understanding the epigenetic contributors to cancer progression and treatment response.

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image: CRISPR Screen Detects Functional Gene Regulation

CRISPR Screen Detects Functional Gene Regulation

By | April 3, 2017

A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences.

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image: Cancer Genomes

Cancer Genomes

By | April 1, 2017

April Scientist to Watch Angela Brooks of the University of California, Santa Cruz, discusses her search to find vulnerabilities buried within the genomes of cancer cells.

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