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tag double strand breaks culture neuroscience

Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Advancing Techniques Reveal the Brain’s Impressive Diversity
Sara B. Linker, Fred H. Gage, and Tracy A. Bedrosian | Nov 1, 2017 | 10+ min read
No two neurons are alike. What does that mean for brain function?
Immune System Maintains Brain Health
Amanda B. Keener | Nov 1, 2016 | 10+ min read
Once thought only to attack neurons, immune cells turn out to be vital for central nervous system function.
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018 | 7 min read
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
labtools march 2019 the scientist dna
The Challenge of Using CRISPR to Knock In Genes
Anna Nowogrodzki | Mar 1, 2019 | 7 min read
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.
DNA, RNA Probes Help Investigators Narrow The Search For Genes
Holly Ahern | Nov 26, 1995 | 10+ min read
For Genes Author: Holly Ahern For a geneticist, pinpointing a mutation in a human gene that might be responsible for an inherited disease can be likened to the proverbial search for a needle in a haystack. While mo-lecular biologists sift through the 3 billion base pairs in the human genome in search of disease-causing genes, other scientists choose to approach the problem from the perspective of the mouse, a model system for mammal research. Because mice and humans are members of the same gr
Notebook
Eugene Russo | Dec 5, 1999 | 7 min read
Contents Pivotal pump Leptin limbo Clue to obesity Biotech Web site Helping hand Mapping malaria Notebook Pictured above are pigmented bacterial colonies of Deinococcus radiodurans, the most radiation-resistant organism currently known. DEINO-MITE CLEANUP In 1956, investigators discovered a potentially invaluable cleanup tool in an unlikely place. A hardy bacterium called Deinococcus radiodurans unexpectedly thrived in samples of canned meat thought to be sterilized by gamma radiation. The b

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