The method to the dengue virus's maddening infectiousness.
The Scientist
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Although fully organized patient-run trials are still few and far between, patients are taking a more active role in clinical research.
The global spread of dengue virus has immunologists and public-health experts debating the best way to curb infection.
Patients are sidestepping clinical research and using themselves as guinea pigs to test new treatments for fatal diseases. Will they hurt themselves, or science?
A study suggests that some mouse models do not accurately mimic human molecular mechanisms of inflammatory response, but other mouse strains may fare better.
One of the most advanced tuberculosis vaccines has failed to protect infants from getting the disease in a clinical trial, but it may be effective in adults.
With dogged persistence and an unwillingness to entertain defeat, Bruce Beutler discovered a receptor that powers the innate immune response to infections—and earned his share of a Nobel Prize.
Some of these insidious viruses expertly subvert the host immune system, allowing their unhindered proliferation.
Researchers and biotech companies are bringing a universal flu vaccine closer to reality.
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