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tag plasmodium disease medicine evolution

a newly hatched mosquito sits on top of water, with its discarded cocoon floating below
In Vitro Malaria Sporozoite Production May Lead to Cheaper Vaccines
Katherine Irving | Jan 20, 2023 | 4 min read
A method for culturing the infectious stage of the Plasmodium lifecycle could increase malaria vaccine production efficiency by tenfold, study authors say.
Evolution, Resisted
Elie Dolgin | Oct 1, 2009 | 10+ min read
Scientists are trying to design the last malaria control agent the world will ever need.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
malaria feature
Are We Headed for a New Era of Malaria Drug Resistance?
Natalie Slivinski | Mar 1, 2019 | 10+ min read
Plasmodium falciparum has shown an ability to evade everything we throw at it, most recently artemisinin-based combination therapies, today’s front-line treatment.
Sporozoite transcriptome
Jonathan Weitzman ((jonathanweitzman@hotmail.com) | Aug 8, 2001 | 1 min read
The protozoan parasite Plasmodium causes malaria, the most serious parasitic disease in humans. The identification of proteins expressed at the infectious sporozoite stage is important for the selection of potential vaccine candidates. In the August 14 Proceedings of the National Academy of Sciences, Stefan Kappe and colleagues from the New York University School of Medicine describe attempts to characterize the sporozoite transcriptome (Proc Natl Acad Sci USA 2001, 98:9895-9900).They construct
Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
Week in Review: June 16–20
Tracy Vence | Jun 20, 2014 | 2 min read
Early Neanderthal evolution; developing antivirals to combat polio; the mouth and skin microbiomes; insect-inspired, flight-stabilizing sensors
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Do Pathogens Gain Virulence as Hosts Become More Resistant?
Andrew F. Read and Peter J. Kerr | Oct 1, 2017 | 10+ min read
Emerging infections provide clues about how pathogens might evolve when farm animals are protected from infection.

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