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tag competition cell molecular biology ecology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
Weathering Hantavirus: Ecological Monitoring Provides Predictive Model
Steve Bunk | Jul 4, 1999 | 7 min read
Photo: Steve Bunk Dave Tinnin, field research associate in the University of New Mexico's biology department, takes blood samples and measurements of rodents caught on the research station grounds. At the end of a freeway exit near Soccoro, N.M., the hairpin turn onto a gravel road is marked by a sign that warns, "Wrong Way." But it isn't the wrong way if you want to reach the University of New Mexico's (UNM) long-term ecological research (LTER) station. The sign's subterfuge is the first indi
Tag! Purifying Proteins with Affinity Chromatography
Aileen Constans(aconstans@the-scientist.com) | Feb 27, 2005 | 6 min read
What is now a standard protein laboratory technique began as an act of desperation.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Bridging Genomics and Proteomics
Deborah Fitzgerald | Jul 21, 2002 | 3 min read
Image: Courtesy of Aclara Biosciences The eTag™ system from ACLARA BioSciences of Mountain View, Calif., enables the multiplexed, solution-phase analysis of proteins and nucleic acids. This technology employs the company's eTag reporters, which are low-molecular weight, fluorescent molecules that are readily separated and quantified by capillary electrophoresis (CE) in conjunction with fluorescence detection using standard capillary DNA sequencers. This method can be used for any applic
A C-fern (Ceratopteris richardii) growing in a pot
Genome Spotlight: C-fern (Ceratopteris richardii)
Christie Wilcox, PhD | Sep 22, 2022 | 5 min read
Sequences for the model organism and two of its kin reveal how these plants got their oversized genomes.
Contributors
The Scientist Staff | Jan 1, 2008 | 2 min read
F. Stuart Chapin III, known as Terry, has been a professor of ecology at the University of Alaska Fairbanks since 1973. He studies the effects of changes in climate and wildfire on Alaskan ecology, with a particular focus on developing sustainable ecosystems and human communities. In this issue, Chapin introduces a five-part feature on the effects of climate change on the biosphere. "Scientific assessments now clearly demonstrate the ecological and societal consequences of huma

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