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tag extracellular matrix genetics genomics

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Thick skinned
Tudor Toma(t.toma@ic.ac.uk) | Apr 8, 2002 | 1 min read
Lipoid proteinosis is caused by mutations in the extracellular matrix protein 1 gene on chromosome 1q21.
An image of lung tissue acquired using a MALDI imaging mass spectrometer.
Glycogen Metabolism May Play a Key Role in Pulmonary Fibrosis
Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read
Researchers discover that glycogen and N-linked glycans accumulate in fibrotic regions of the lung and may be important for therapy development.
Location, Location, Location
Anna Azvolinsky | Apr 1, 2017 | 9 min read
Since first proposing that a cell’s function and biology depend on its surroundings, Mina Bissell continues to probe the role of the extracellular matrix.
The Psychiatrist’s Jigsaw
Megan Scudellari | Nov 1, 2013 | 10+ min read
Researchers are piecing together the devilishly complex sets of genetic alterations underlying schizophrenia and bipolar disorder.
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Cancer cell
Interrogating the Complexities of the Tumor Microenvironment
Alison Halliday, PhD, Technology Networks | May 19, 2023 | 5 min read
Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.
a smiling woman standing between a much taller man and woman
Protein Size Matters
David Adam | Sep 23, 2021 | 3 min read
A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function.
Genome Economy
Ricki Lewis | Jun 10, 2001 | 10 min read
The Human Genome Project's discovery1 that the human body runs on an instruction manual of a mere 35,000 or so genes--compared to the worm's 19,000, the fruit fly's 13,000, and the tiny mustard relative Arabidopsis thaliana's 25,000--placed humanity on an even playing field with these other, supposedly simpler, organisms. It was a humbling experience, but humility quickly gave way to awe with the realization that the human genome might encode 100,000 to 200,000 proteins. Scientists base this num
Arabidopsis Genome
Barry Palevitz | Jan 7, 2001 | 8 min read
Courtesy National Science Foundation Headlines on the morning of December 14, 2000, trumpeted the end of a presidential election that promised to go on forever. But if California Institute of Technology molecular biologist Elliot Meyerowitz had his way, the front page would have read differently: "Plant Genome Sequenced" at the top, then, lower down, "Election Decided - See Page 2." In a tour de force that capped a year of genome blockbusters, European, Japanese, and American scientists complet

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