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tag photobleaching genetics genomics

Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
A Thousand Points of Light
Bob Sinclair | Oct 15, 2000 | 10+ min read
Not so long ago, researchers had somewhat limited choices for locating and following a particular piece of DNA. A probe could be labeled using radioactivity, by kinasing an end or nick-translating the whole piece. A fragment of interest could be visualized (along with all other DNA and RNA species in the preparation) using ethidium bromide. With sufficient skill and patience an investigator could obtain from these rather crude techniques fairly impressive information, such as the precise 5' end
Strike Up the Band
Michael Brush | Feb 20, 2000 | 8 min read
Gel Documentation and Analysis Systems Gel Documentation and Analysis Systems (continued) Alpha Innotech's FluorChem His name was Herman. The kindly, silver-haired Estonian immigrant ran the department photography shop. Anybody needing to capture an image of a Coomassie or silver-stained protein gel let Herman work his magic with light box, camera, and developing solutions. He started by asking the researcher to carefully position the gel on his light box. Next, he installed the proper filter a
Recourse to Death
Michael Brush | Aug 20, 2000 | 10 min read
Manufactureres of Flow Cytometry Products for Apoptosis Detection To examine the causes of life, we must first have recourse to death," uttered Victor Frankenstein upon beginning his search for the source from "whence the principle of life proceeds" and ultimately creating his nameless monster. Frankenstein's real creator, 19-year-old Mary Shelley, probably had no idea when Frankenstein was first published in 1816 that her main character's motivation would eventually have real-life implication

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