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tag cell and molecular biology developmental biology genetics genomics cell molecular biology

Molecular Biology
The Scientist Staff | May 12, 1991 | 2 min read
R.G. Goodwin, D. Friend, S.F. Ziegler, R. Jerzy, et al., "Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily," Cell, 60:941-51, 1990. Raymond Goodwin (Immunex Corp., Seattle): "Interleukin-7 (IL-7) was cloned based on its ability to induce the proliferation of pre-B cells, and has subsequently been shown to have effects on immature and mature T cells. The cloning of the receptor for IL-7 allows for studies to iden
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
Molecular Biology
The Scientist Staff | Jan 19, 1992 | 1 min read
S. Ghosh, A.M. Gifford, L.R. Riviere, P. Tempst, et al., "Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal," Cell, 62:1019-29, 1990. Sanker Ghosh (Yale University School of Medicine; formerly at Whitehead Institute for Biomedical Research, Cambridge, Mass.): "NF-kB is a transcription factor that is widely used for the inducible expression of a large number of cellular and viral genes. This has resulted in the study of NF-kB by researchers interested in diverse areas
Molecular Biology
The Scientist Staff | Feb 20, 1994 | 2 min read
S. Matsuda, H. Kosako, K. Takenaka, K. Moriyama, H. Sakai, T. Akiyama, Y. Gotoh, E. Nishida, "Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade," The EMBO Journal, 11:973-82, 1992. Eisuke Nishida (Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Japan): "MAP kinases have been described as serine/threonine kinases that are acti
Developmental Biology
The Scientist Staff | Jan 3, 1999 | 3 min read
L.B. Zimmerman, J.M. De Jesús-Escobar, R.M. Harland, "The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4," Cell, 86:599-606, 1996. (Cited in more than 180 papers since publication) Comments by Richard M. Harland, Choh Hao Li professor of biochemistry and molecular biology, University of California, Berkeley Richard M. Harland Researchers had long suspected that the protein noggin's interaction with bone morphogenetic proteins (BMPs) dictated devel
Molecular Biology
The Scientist Staff | Oct 25, 1992 | 2 min read
A. Simeone, D. Acampora, V. Nigro, A. Faiella, M. D'Esposito, A. Stornainolo, et al., "Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells," Mechanisms of Development, 33:215-228, 1991. Edoardo Bonicelli (H. S. Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy): "This paper put some order into the zoo of vertebrate homeobox genes controlling positional information necessary for the appropriate body s
Molecular Biology
The Scientist Staff | Dec 9, 1990 | 1 min read
S. Hahn, S. Buratowski, P.A. Sharp, L. Guarente, "Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions," Cell, 58, 1173-81, 22 September 1989. Steven Hahn (Fred Hutchinson Cancer Research Center, Seattle): "TFIID is one of the essential components in the machinery necessary to initiate transcription by RNA polymerase II. For eight years after the discovery of TFIID in mammals, little was known about it because of
Molecular Biology
The Scientist Staff | Oct 11, 1992 | 2 min read
A. Kakizuka, W.H. Miller, K. Umesono, R.P. Warrell, et al., "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR with a novel putative transcription factor, PML," Cell, 66:663-74, 1991. Akira Kakizuka (The Salk Institute, La Jolla, Calif.): "Our paper described the genes located at each of the breakpoints of the t(15;17) translocation associated with human acute promyelocytic leukemia (APL). In addition to the karyotype abnormality, the patients with APL can be i
Molecular Biology
Osamu Chisaka | Aug 16, 1992 | 1 min read
Osamu Chisaka (University of Utah School of Medicine, Salt Lake City): “This paper is the first report about mice with an inactivated Hox gene— mammalian homologues of fruit fly homeotic genes that define segmented structures of the body through the anterior-posterior axis. This paper has been 'hot' partly because there are 40 or so closely related Hox genes in the mammalian genome, and many researchers have been investigating their functions. In addition, this paper not only describ
Molecular Biology
The Scientist Staff | Nov 14, 1993 | 2 min read
p.17 A.A. Levin, L.J. Sturzenbecker, S. Kazmer, T. Bosakowski, C. Huselton, G. Allenby, J. Speck, C. Kratzeisen, M. Rosenberger, A. Lovey, J.F. Grippo, "9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa," Nature, 355:359-61, 1992. Arthur A. Levin and Joseph F. Grippo (Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, N.J.): "The biologic activities of the all-trans (t) isomer of retinoic acid (RA) are mediated through the binding and activati

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