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tag hiv pathogenesis culture immunology disease medicine

Illustration of HIV virus
Viral Protein Behind Chronic Inflammation in People with HIV: Study
Natalia Mesa, PhD | Dec 12, 2022 | 3 min read
The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 
3D image of a neuron cell network with a red glow representing inflammation.
New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment 
Deanna MacNeil, PhD | Jun 1, 2023 | 2 min read
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
The Vaginal Microbiome is Finally Getting Recognized
Hannah Thomasy, PhD, Drug Discovery News | Sep 25, 2023 | 10+ min read
Vaginal dysbiosis has long been a taboo subject, but studying and optimizing the vaginal microbiome could be a game changer for women's health.
3D medical illustration of peripheral blood cells: a lymphocyte (left) and a monocyte (right) surrounded by red blood cells.
PBMCs: Mononucleated and Multipurposed
Deanna MacNeil, PhD | Dec 16, 2022 | 4 min read
Researchers employ peripheral blood mononuclear cells (PBMCs) in clinical and academic applications related to the immune system and regenerative medicine.
How HIV Destroys Immune Cells
Dan Cossins | Dec 19, 2013 | 4 min read
During HIV infection, CD4 T cells in lymphoid tissues initiate a highly inflammatory form of cell death that helps cripple the immune system.
 
Two-Faced Proteins May Tackle HIV Reservoirs
Amanda B. Keener | Oct 21, 2015 | 3 min read
Researchers design antibody-like proteins to awaken and destroy HIV holdouts.
Illustration of viruses represented with different colors overlapping each other.
What Happens When You Catch More than One Virus?
Alejandra Manjarrez, PhD | Dec 7, 2022 | 8 min read
The “tripledemic” shines a spotlight on viral interference, in which one infection can block another.
“Public” T-Cell Receptors From Resistant People Fend Off HIV
Shawna Williams | Jun 8, 2018 | 4 min read
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.
Immunology Needs a '70s Groove
Richard Gallagher | Jan 26, 2003 | 2 min read
Turn to page 10 of this issue to view a first-rate Eureka moment, a full-blown YOOOO-REEEEEEE-KAAA epiphany: a photograph of the lab notebook page recording the discovery of the virus now known as HIV. The document deserves prominent display in a major museum. However, when I contacted author Francoise Barré-Sinoussi to ask for it, the reply was, and I paraphrase, "I should have that somewhere, let me get back to you." Who says that researchers are all egomaniacs? Since the discovery
A silver tree showing roots and branches in a circle on a blue background.
Onward and Upward!
Kristie Nybo, PhD | Sep 8, 2023 | 9 min read
At The Scientist, we are strengthening our roots while reaching for the sky.

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