Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 

A snapshot of the most highly ranked articles in genomics, genetics and related areas, from Faculty of 1000

Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.

Adding RNA sequencing analysis to genomic sequencing helps scientists uncover mutations likely responsible for genetic disorders they might otherwise miss.

To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

J. Craig Venter is no stranger to contradiction and controversy. He seems to thrive on it. In 1991, when the National Institutes of Health was haggling over patenting expressed sequence tags (ESTs)--a shortcut to identifying protein-encoding genes--Venter the inventor accepted a private offer to found The Institute for Genomic Research (TIGR) in Rockville, Md. TIGR would discover ESTs and give most of them to a commercial sibling, Human Genome Sciences (HGS), to market. ESTs are now a standard

In 1996, Jeff Trent and colleagues published the first paper describing DNA microarrays as tools for pinpointing gene variants underlying various tumor properties.1 Now, as president and scientific director of Translational Genomics Research Institute (TGEN), in Phoenix, Trent is using microarrays to look for gene expression patterns that can be applied to developing diagnostics. The role of microarrays, Trent says, "will be on the discovery side. Testing all 30,000 genes against a diagnosti

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.