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Mass Spectrometry Applications for Proteomics
Jeffrey Perkel | Aug 19, 2001 | 10+ min read
Click to view the PDF file: Proteomic Mass Spectrometry Equipment Courtesy of CiphergenCiphergen's SELDI process, a MALDI variant that includes a surface-based enrichment step Early in the twentieth century, scientists puzzled over the observation that certain elements that were otherwise physically indistinguishable from each other nevertheless exhibited different radioactive decay characteristics. These elements would ultimately come to be known as isotopes, but at the time this concept was
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Biochemical, Reagents Kits Offer Scientists Good Return On Investment
Holly Ahern | Jul 23, 1995 | 8 min read
Investment Author:Holly Ahern If you were to ask several life scientists to name a particular biochemical product that they simply could not do without, you'd probably get a myriad of answers that would mirror the research interests of the group you questioned. A molecular evolutionist trying to differentiate two closely related species of monkeys by restriction fragment-length polymorphism (RFLP) analysis might cite restriction enzymes, which can cut DNA into pieces of varying length. A cell b
Top 10 Innovations 2016
The Scientist | Dec 1, 2016 | 10+ min read
This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.
Phospho-Mania
Aileen Constans | Nov 7, 2004 | 6 min read
ERK1/2 ACTIVATIONCourtesy of Biosource Internationalis plainly visible in heart tissue from an MHC-Rac1 transgenic mouse (right), compared with its normal counterpart (left). Green, pERK 1/2 (pTEpY185/187); blue, actin; red, nuclei.Protein phosphorylation is one of the most widely studied posttranslational modifications, with good reason. Many cellular signaling events rely on the addition or subtraction of phosphate groups (by kinases and phosphatases, respectively) to serine, threonine, and ty
Top 10 Innovations 2015
The Scientist | Dec 1, 2015 | 10+ min read
The newest life-science products making waves in labs and clinics
Small - It Isn't One Size Fits All
James Kling | Sep 14, 1997 | 10+ min read
Date: September 15, 1997 Comparison Chart HPLC is an essential work-horse for most bio-laboratories. Without a functioning system, the days of gravity columns-once a not-so-fond, distant memory-can return with a vengeance. And a system that no longer fits your research needs can collect dust like so much scrap metal. In choosing an instrument, consider the demands your research will place on it. For example, determine what type of solvents you will most often use. Solvent compatibility of th
All's Well that Ends Well: A Profile of Specialty Microwell Plates
Brent Johnson | Sep 26, 1999 | 10+ min read
Date: September 27, 1999Table of Specialty Microplates The story of the microplate is one of those tales of history that either has been forgotten or was never clearly understood. According to Barry Lazar of Dynex Technologies, formerly Dynatech Laboratories, the origin of what is now commonly referred to by Dynex's registered trademark of Microtiter plates began with Gyola Takatsy, a Hungarian-born scientist who was trying to scale down serology tests. His first prototype became available in 1
Ten Technologies in Five Years
Sam Jaffe(sjaffe@the-scientist.com) | Dec 5, 2004 | 8 min read
When scientists make long-term research plans, they must try to anticipate how emerging technologies will influence their work in the coming years.

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