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tag bp evolution

Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Targeted Comparative Sequencing Illuminates Vertebrate Evolution
Ricki Lewis | Dec 8, 2002 | 6 min read
Image: Courtesy of Elliott Marguiles  PIPS ON PARADE: Researchers used a MultiPipMaker to show the alignments, expressed as percent identity plots, between a human reference sequence and several other species. This is a 20 kb region surrounding exon 2 of the MET gene. Gap-free alignable segments are represented as horizontal lines along the human reference sequence; the line's height represents the identity of that alignment. Aristotle envisioned humanity as the pinnacle of a "Great Chai
Checking the Alignment
Jane Salodof Macneil | Sep 21, 2003 | 9 min read
Courtesy of European Bioinformatics Institute  KNOWLEDGE GAPS? Sequence alignments offer clues to both the function and evolution of novel genes. But a bewildering array of algorithms and parameters leaves many researchers unable to use these programs to their fullest potential. In the beginning, there was Needleman-Wunsch, which begat Smith-Waterman, which begat FASTA, which begat BLAST, and so on. Peel away the information technology jargon surrounding these alignment algorithms, and a
Creative Emulsification
Sabrina Richards | Nov 1, 2012 | 8 min read
Enhancing data collection from emulsion PCR reactions: three case studies
Assays Galore
Lanette Fee | Sep 21, 2003 | 9 min read
Courtesy of BD Biosciences Pharmingen  COLOR CODING: Multiplexed bead-based assays, like BD Biosciences' Cytometric Bead Array (shown), test for multiple analytes in a single vial. The key is in the colors: one hue indicates the bead ID, and the intensity of the second, how much protein has been captured. In today's fast-paced research environment, technologies for speedy, cost-efficient analyses reign supreme. As part of this general trend, techniques for multiplexing, that is, simultan
Combinatorial Libraries: Life's Tinker Toys
Gail Dutton | May 18, 2003 | 9 min read
Courtesy of UC Davis Medical Center  COMBI-KING: Kit Lam brings his expertise in combinatorial chemistry, an innovative technique for creating millions of new chemical compounds in just days, to the UC Davis Cancer Center. It's the new mix and match. In the computer industry, programmers refer to modularity--the ability to shuffle different sections of computer code to create new software. In the life sciences, the modules are peptides or molecular fragments that can be combined to yield
The Array of Today
Jorge Cortese | Sep 3, 2000 | 10 min read
Human Arrays Human Arrays (continued) A 20th century scientist may have spent an entire career studying the function of a single protein, never imagining that one day it would be possible to study every human gene at once. This capability comes in the form of a microarray, a surface collection of immobilized genes that can be simultaneously examined with specialized equipment.1 Many current applications of arrays, also known as biochips, can be used in functional genomics as scientists seek ch
Deviations From The Norm: Systems For Mutation Detection Reveal Hidden Potentials
Kailash Gupta | Jul 18, 1999 | 10+ min read
Date: July 19, 1999Mutation Detection Systems and Methods Affymetrix's p53 chip Researchers leading the Human Genome Project (HGP) originally envisioned completion of the entire genome sequence (approximately 3 billion base pairs) by the year 2005. Recently the arena of human genome sequencing has seen a lot of heat generated by the entry of both commercial entrepreneurs and public consortia. Celera, a company formed by highly skilled and competent commercial organizations (TIGR and Perkin-Elm
Senior Scientists Quit Europe
Silvia Sanides | Jun 1, 2003 | 7 min read
©Paul Barton, Corbis Rigid retirement policies are prompting scientists to flee Europe at the height of their professional lives to start second careers in the United States. Many of these researchers are still conducting experiments and are in no mood to slow down. But because nearly all European universities are government run, professors are left little choice when they reach mandatory retirement age, which in most countries is 65 years or even younger. Some scientists leaving for the
Ribozymes: Hearkening Back to an RNA World
Jeffrey Perkel | Sep 15, 2002 | 9 min read
Illustration: Ned Shaw LIKE MOLECULAR TOY-MAKERS, ribozyme researchers create tools with evolutionary, diagnostic, and therapeutic applications. Nearly 20 years ago, Tom Cech and Sidney Altman discovered that some naturally occurring RNAs could perform enzymatic reactions, earning these researchers the 1989 Nobel Prize in chemistry. Scientists have now identified several examples of RNA enzymes, or ribozymes. Most make or break the phosphodiester bonds in nucleic acid backbones, but some

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