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Elias A. Zerhouni
Ted Agres | Jul 7, 2002 | 4 min read
In the mid-1980s, cardiologists faced a particularly vexing problem: how to measure, accurately and noninvasively, the thickness of heart tissue as it changed over time. Elias A. Zerhouni, a young radiology professor at Johns Hopkins School of Medicine, struggled over the issue with a small team of physicists. "One day, he walked into the room with this incredible smile on his face, like you would have if you made a great molecular discovery," recalls Myron Weisfeldt, director of Hopkins' Depart
Liquid-Handling Equipment Evolves To Suit Large-Scale Applications
Ricki Lewis | Jan 5, 1997 | 9 min read
Sidebar: Selected Suppliers of Liquid-Handling Equipment Liquid-handling equipment has always been central to biomedical research. Pipettes and pumps must be accurate and resist contamination, yet work quickly and comfortably in repetitive procedures. While pipettes and pumps will remain key components of experimental protocols, new types of large-scale research will require more automation and miniaturization in liquid-handling capabilities. Both the Human Genome Project and combinatorial che
New Technology Spurs on Proteomics
Jennifer Fisher Wilson | Apr 1, 2001 | 7 min read
Graphic: Leza BerardoneOne recent morning at the Applied Biosystems proteomics research center in Framingham, Mass., scientist Jason Marchese patiently used a pipettor to place tiny samples onto a 2-inch-by-2-inch plate. He was surrounded by technology as simple as 2-D gel electrophoresis apparatus and as cutting-edge as a high-throughput system that uses automated robotics for multidimensional liquid chromatography separation of proteins and an automated workstation that uses the latest in mass
Week in Review: June 16–20
Tracy Vence | Jun 20, 2014 | 2 min read
Early Neanderthal evolution; developing antivirals to combat polio; the mouth and skin microbiomes; insect-inspired, flight-stabilizing sensors
Variations on a Gene
Amy Francis | Jul 23, 2000 | 10+ min read
Photodisc Although President Bill Clinton surely had something in mind during his 2000 State of the Union address when he asked the nation to "celebrate our diversity," insights into human diversity at the molecular level are promising to speed drug discovery and revolutionize medicine to mark- edly improve human health. Individuals differ at one in 1,000 base pairs, which adds up to a whopping number of human genetic variations when applied to the roughly three billion base pairs of the human g
Charting the Microarray Revolution
Mark Schena | Oct 10, 2004 | 5 min read
In the early 1990s, my colleagues and I at Stanford University began tinkering with an interesting weed, the small flowering mustard plant, Arabidopsis thaliana. We set out to study genes involved in controlling the growth and appearance of this lauded model organism, and using molecular cloning and transgenics, we identified a novel family of plant homeobox genes.This experiment proved valuable in a number of respects. First, we showed we could hasten or slow the rate of plant development by al
The Chipping News
Aileen Constans | Apr 28, 2002 | 10+ min read
Recent months have seen a surge of activity in the field of protein microarrays. No wonder: Gene expression-profiling is faster and more powerful thanks to improvements in DNA microarray technology. Now researchers want to apply these benefits to boost the speed of proteomics research. But developing these tools is not easy, as protein arrays present technical challenges not faced by DNA microarray manufacturers. "You can attach any two pieces of DNA the same way and expect [them] to behave the
One Step Beyond: Going Beyond Genomics With Proteomics And Two-Dimensional Gel Technology
Laura Defrancesco | Jan 3, 1999 | 10+ min read
Proteomes and 2D Gel Apparatus Providers Big science has moved on to proteins. With the new brand of science termed proteomics--named by the Australians Marc Wilkins and Keith Williams to mean the "set of PROTEins encoded by the genOME"--the push is on around the globe to produce a complete description of a cell/tissue/organism in terms of the proteins produced. The challenge is all the greater because the expressed protein pattern changes with time and environment--responding to developmenta

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