Jonathan Weitzman(jonathanweitzman@hotmail.com) | Jul 23, 2001 | 1 min read
The repressor-activator protein 1 (Rap1) binds to [C(1-3)A]n repeats, acts as a transcriptional activator, and represses gene expression at telomeres by binding to the accessory silencing proteins Sir2, Sir3 and Sir4. In the Advance Online Publication of Nature Genetics, Lieb and colleagues, at Stanford University, describe a study to investigate the genome-wide DNA-binding specificity of Rap1 and Sir proteins in vivo (Nature Genetics 2001 DOI:10.1038/ng569). They performed chromatin immunopreci