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tag chromosome folding domains developmental biology culture

Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Going Beneath the Fold
Robert Mahley and Yadong Huang | Aug 1, 2006 | 10+ min read
FEATUREProtein Misfolding Transmission Electron Micrograph of Protein Filaments in Alzheimer's DiseaseCOURTESY OF HUNTINGTON POTTERHow an apolipoprotein E isoform wreaks havoc in the brain, and what we might be able to do about itBY ROBERT MAHLEY AND YADONG HUANGFor much of the 20th century, scientists have looked at brain cells from patients with Alzheimer's disease (AD), Huntington's disease, and other neurodeg
Archaea Family Tree Blossoms, Thanks to Genomics
Amber Dance | Jun 1, 2018 | 10+ min read
Identification of new archaea species elucidates the domain’s unique  biology and sheds light on its relationship to eukaryotes.
Artist’s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
Chromosome Analysis Goes High Tech
Ricki Lewis | Oct 15, 1989 | 5 min read
Since the 1 920s, when researchers began to study chromosomes, the analysis of human chromosomes has presented a particularly tough technological challenge, simply because there are so many of them. When displayed under a light microscope. the strands of human genetic material tend to bunch together maddeningly, overlapping and intertwining like so much spaghetti. For these reasons, it wasn’t until 1956 that the correct number of 46 human chromosomes (23 pairs) was clearly demonstrated.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020 | 10+ min read
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
A mutated cell with a spiky membrane
Mutations in Autism-Linked Gene Cause Membrane Mischief
Holly Barker, PhD, Spectrum | Jan 26, 2023 | 4 min read
Inactivating TAOK1 prompts tentacle-like protrusions to form all over a neuron’s surface, revealing the gene’s role in molding the membrane.
Valerie Arboleda Uses Big Data to Unravel the Biology of a Rare Disease
Shawna Williams | May 1, 2018 | 3 min read
The UCLA geneticist examines how defects in a histone protein lead to symptoms throughout the body.

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