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tag chromosome folding domains evolution immunology microbiology

One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Archaea Family Tree Blossoms, Thanks to Genomics
Amber Dance | Jun 1, 2018 | 10+ min read
Identification of new archaea species elucidates the domain’s unique  biology and sheds light on its relationship to eukaryotes.
Artist’s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Woman in face shield and blue gown taking cotton swab of patient's mouth while patient sits inside of car
What You Should Know About New Omicron Subvariants
Natalia Mesa, PhD | May 17, 2022 | 6 min read
The presence and spread of new, more-infectious and immune-evading variants show that the coronavirus is not done mutating.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
A Movable Defense
Eugene V. Koonin and Mart Krupovic | Jan 1, 2015 | 10 min read
In the evolutionary arms race between pathogens and hosts, genetic elements known as transposons are regularly recruited as assault weapons for cellular defense.
Life Science
Simon Silver | Jan 7, 1990 | 6 min read
Department of Microbiology & Immunology University of Illinois Chicago - Through cloning and sequence analysis, researchers have identified the primary gene of the hereditary disease muscular dystrophy, thus leading to the characterizing of the primary protein product. Deletions contributing to an absence of the polypeptide dystrophin (0.002% of total muscle protein and 3,685 amino acids long) on the inner surface of the plasma membrane appear to be the primary cause for two types of muscul
Notable
Jeffrey Perkel | Jan 20, 2002 | 3 min read
T. Sicheritz-Pontén, S.G. Andersson, "A phylogenomic approach to microbial evolution," Nucleic Acids Research, 29[2]:545-52, Jan. 15, 2001. F1000 Rating: Must Read "The paper describes methods and computer programs for automated phylogenetic analysis of complete genome datasets, as well as useful visualization tools for the results. The tools should be useful to those looking for genes that may have unusual evolutionary histories relative to other genes in the same genome." —Jonath
Crohn's: An Autoimmune or Bacterial-Related Disease?
Maria Anderson | Aug 19, 2001 | 8 min read
In 1996 geneticist Gilles Thomas and colleagues at the INSERM, the French Institute for Health and Medical Research in Paris, reported that IBD1, a region on the long arm of chromosome 16, was a Crohn's disease susceptibility locus.1 Five years later, in a second study, they announced that they had pinpointed the exact gene. The researchers contended that the connection between Crohn's and NOD2, the implicated gene located in IBD1, provided evidence to support the hypothesis that the disease is

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