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tag protein protein interactions neuroscience disease medicine

A false color transmission electron microscope micrograph showing the nuclear envelope, the rough endoplasmic reticulum, the nucleus, and the cytoplasm.
New Gene Mutants Identified in Rare Motor Neuron Diseases
Clare Watson | Oct 17, 2022 | 2 min read
The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.
DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
The mitochondria inside of a neuron are shown in red. The neuron’s protrusions called dendritic spines are shown in cyan.
How Mitochondria Stay Still in Neurons
Mariella Bodemeier Loayza Careaga, PhD | Mar 13, 2024 | 5 min read
An endoplasmic reticulum associated protein holds mitochondria in place in dendrites. This spatial stabilization possibly provides a local energy source for synaptic plasticity. 
Professor Alexandra Whiteley and graduate student Autumn Matthews look at an image of a western blot on their laboratory computer.
An Ancient Viral Protein May Play a Key Role in ALS
Aditi Subramaniam, PhD | Aug 15, 2023 | 4 min read
Researchers find that UBQLN2 gene dysfunction causes a virus-like protein to accumulate in cells, which changes gene expression and may contribute to disease progression in amyotrophic lateral sclerosis (ALS).
Neurodegenerative Diseases: Peering in on Protein Interactions
The Scientist Marketing Team | Sep 6, 2016 | 1 min read
The Scientist is bringing together a panel of experts to share their experience with novel methods for analysis of protein-protein interactions in the brain.
Infusion of Artificial Intelligence in Biology
Meenakshi Prabhune, PhD | Feb 23, 2024 | 10 min read
With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.
Probing Protein Interactions
Laura Defrancesco | Apr 14, 2002 | 8 min read
The challenge of proteomics is personified in the Greek god, Proteus. The keeper of all knowledge, past, present and future, Proteus would not give up any information easily; even while held down, he would struggle and assume different forms before giving anything up. Remarkably, proteomics, and proteins for that matter, were not named after Proteus, but the imagery could not be more fitting. It's still anyone's guess what the final gene count will be in the human genome, let alone the total nu
Amyloid plaques on axons of neurons
The Misunderstood Proteins of Neurodegeneration
Catherine Offord | Aug 1, 2022 | 10+ min read
The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
3D rendered medical illustration of neurons containing Lewy bodies (small red spheres), accumulated proteins in brain cells that cause degeneration and are linked to Parkinson’s disease.
The Bigger Protein Picture of Designing Parkinson’s Therapeutics
Deanna MacNeil, PhD | Feb 13, 2023 | 3 min read
Researchers highlight protein structure considerations for designing inhibitors that target familial Parkinson’s disease mutations.
Illustration of HIV virus
Viral Protein Behind Chronic Inflammation in People with HIV: Study
Natalia Mesa, PhD | Dec 12, 2022 | 3 min read
The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

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