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tag sodium balance genetics genomics immunology

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Immune to Failure
Karen Hopkin | Feb 1, 2013 | 9 min read
With dogged persistence and an unwillingness to entertain defeat, Bruce Beutler discovered a receptor that powers the innate immune response to infections—and earned his share of a Nobel Prize.
Those We Lost in 2018
Ashley Yeager | Dec 26, 2018 | 10+ min read
The scientific community said goodbye to a number of leading researchers this year.
Using Transgenesis to Create Salt-Tolerant Plants
Ricki Lewis | Mar 3, 2002 | 6 min read
Crop agriculture has succeeded because growers have identified and cultivated useful plant variants through selective breeding and environmental alterations. Transgenic technology improves the precision of agriculture, modifying crops in ways that are uniquely useful that probably would not have arisen naturally. Salt tolerance is one such coveted trait. Recent research on promoting salt tolerance through transgenesis focuses on boosting salt-sequestering physiological mechanisms within species,
A New View of Translational Control
Charles Choi(cchoi@the-scientist.com) | Dec 4, 2005 | 7 min read
The bank note that Dominique Weil used to buy ice cream for her family at the beach this past summer may have traveled a long way.
Notable
Jeffrey Perkel | Jan 6, 2002 | 4 min read
J.A. Camarero et al., "Peptide chemical ligation inside living cells: In vivo generation of a circular protein domain," Bioorganic and Medicinal Chemistry, 9[9]:2479-84, September 2001. F1000 Rating: Recommended "To investigate whether chemo-selective peptide ligations work in vivo, the authors demonstrate the in vivo head-to-tail cyclization of a bioactive SH3 domain using native chemical ligation. The protein precursor was constructed using a clever combination of an intein-fusion protein an
Stopping the Cane Toad
Brendan Borrell | Apr 1, 2008 | 9 min read
Stopping the Cane Toad When Australian scientists failed to find a virus to control one of the most insidious invasive species, they decided to build one. Is it worth the risk? By Brendan Borrell All photos by Brendan Borrell Related Articles: 1 "Everyone was very excited about that," he says, because it meant that there might be a pathogen that would kill the cane toad and only the cane toad. In 1993, CSIRO received another $2 million AUD ($1.4
A Look at Drosophila Pattern Formation
Jeffrey Perkel | Sep 2, 2001 | 9 min read
Researchers interested in gene expression studies adopt one of two approaches. They can either examine the expression of a given gene in a population of cells in aggregate, or they can study the gene on a cell-by-cell basis in situ. The advantage of the former approach is its simplicity: It is generally easy to prepare RNA or protein from a given tissue sample and to probe it for the gene or protein of interest. But there are several disadvantages associated with the population approach. First o

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