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Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
immunotherapy, immunology, disease & medicine
Contributors
The Scientist | Jul 13, 2020 | 3 min read
Meet some of the people featured in the July/August 2020 issue of The Scientist.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Catherine Offord | Jan 24, 2020 | 4 min read
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020 | 2 min read
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Does the Microbiome Help the Body Fight Cancer?
Catherine Offord | Jul 10, 2019 | 4 min read
Research in mice and humans is beginning to establish a link between the composition of microbes in the gut and immune responses to tumor cells, but the mechanisms are not yet clear.
Peanut Allergy Immunotherapy Increases Anaphylaxis Risk: Study
Kerry Grens | Apr 26, 2019 | 2 min read
Although the oral treatment seems to work, an analysis of the results from 12 clinical trials finds kids who got an immunotherapy have a greater rate of serious reactions.
A Revised CAR T for Lymphoma Has Fewer Side Effects
Kerry Grens | Apr 23, 2019 | 2 min read
An early-stage clinical study finds that none of the 25 patients treated developed neurotoxicity or cytokine release syndrome, common hazards of the cancer immunotherapy.
The Next Frontier of CAR T-Cell Therapy: Solid Tumors
Kerry Grens | Apr 1, 2019 | 10+ min read
The technology has wowed the field by all but obliterating some patients’ blood cancers, but solid malignancies present new challenges.
Infographic: CAR-T Cells in Solid Versus Liquid Cancers
Kerry Grens | Apr 1, 2019 | 2 min read
Tumor accessibility, heterogeneity, and microenvironment vary between the two classes of malignancies.
Opinion: Learning from Immunotherapy’s Recent Failures
Luis Felipe Campesato | Aug 1, 2018 | 6 min read
The promise of immunotherapy is real. We now need to figure out how to maximize the number of patients the approach benefits.
Natural Killer Cells Prove Effective as a CAR Therapy in Mice
Katarina Zimmer | Jul 6, 2018 | 4 min read
Stem-cell–derived natural killer cells engineered in a similar way to CAR-T cells may pave the way to “off the shelf” cancer therapies that aren’t patient-specific.
“Public” T-Cell Receptors From Resistant People Fend Off HIV
Shawna Williams | Jun 8, 2018 | 4 min read
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.
New Insights to Improve CAR T Cells’ Safety
Vicki Brower | Jun 5, 2018 | 4 min read
Drugs approved to treat rheumatoid arthritis block cytokines, the molecules responsible for severe side effects from the immunotherapy, and reduce symptoms in mice.
A T-Cell Tweak Combats Advanced Breast Cancer
Ashley Yeager | Jun 5, 2018 | 2 min read
The immunotherapy eliminated a woman’s metastatic lesions and kept her disease-free for two years.
Immunotherapy Drug Shows Promise for Melanoma, Lung Cancer
Sukanya Charuchandra | Jun 4, 2018 | 2 min read
Merck’s Keytruda extended the lives of lung cancer patients by several months and appeared to stop the progression of advanced melanoma.