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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: Infographic: Antibody Cancer Therapy

Infographic: Antibody Cancer Therapy

By | April 1, 2017

An experimental technique removes T cells that aid in vitro tumor growth.

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image: Infographic: Targeting Cancer Antigens

Infographic: Targeting Cancer Antigens

By | April 1, 2017

Neoantigens may serve as valuable targets for new immunotherapies.

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image: Targeting Tregs Halts Cancer’s Immune Helpers

Targeting Tregs Halts Cancer’s Immune Helpers

By | April 1, 2017

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.

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image: Study: Diet Contributes to Brain Size

Study: Diet Contributes to Brain Size

By | March 30, 2017

The results of a historical primate behavior analysis suggest that species with fruit-filled diets evolved larger brains.

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image: Dinosaur Phylogenetic Tree Shake-Up

Dinosaur Phylogenetic Tree Shake-Up

By | March 24, 2017

An analysis of 74 dinosaur species leads a group of researchers to reorganize the extinct animals’ evolutionary history.

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image: Sharks May Have Evolved from Acanthodians

Sharks May Have Evolved from Acanthodians

By | March 14, 2017

Analysis of an ancient shark fossil provides the strongest evidence to date that modern sharks derive from a class of 400 million–year-old bony fish.

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image: Tasmanian Devil Cancer Immunotherapy

Tasmanian Devil Cancer Immunotherapy

By | March 13, 2017

Researchers in Australia claim to have successfully used immunotherapy to treat devil facial tumor disease.

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