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The Scientist

» ancient DNA and cell & molecular biology

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image: Setbacks and Great Leaps

Setbacks and Great Leaps

By | April 1, 2015

The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.

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image: Signaling Resistance

Signaling Resistance

By | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Yvonne Saenger: Immunotherapy Pioneer

Yvonne Saenger: Immunotherapy Pioneer

By | April 1, 2015

Assistant Professor, Department of Medicine, Columbia University. Age: 41

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image: From Many, One

From Many, One

By | April 1, 2015

Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?

4 Comments

image: Resisting Cancer

Resisting Cancer

By | April 1, 2015

If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.

7 Comments

image: Short, Strong Signals

Short, Strong Signals

By | March 25, 2015

Methylation increases both the activity and instability of the signaling protein Notch.

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image: Ancient Beasts Classified by Collagen

Ancient Beasts Classified by Collagen

By | March 19, 2015

Protein extracted from ancient fossils identified by Darwin as some of the “strangest animals ever discovered” places the creatures amongst horses, tapirs, and rhinos on the tree of life.

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image: Irisin Skepticism Goes Way Back

Irisin Skepticism Goes Way Back

By | March 18, 2015

Post-publication peer reviewers had questioned data about the supposed fat-browning enzyme from the get-go.

1 Comment

image: Growth Hormone Guidance

Growth Hormone Guidance

By | March 1, 2015

Intact growth hormone signaling pathways are needed for methionine restriction to extend mouse lifespan.

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