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image: Massively Parallel Perturbations

Massively Parallel Perturbations

By | March 1, 2017

Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.

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image: Infographic: Single-Cell CRISPR Screens

Infographic: Single-Cell CRISPR Screens

By | March 1, 2017

See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.

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image: Deep Pocket Exploration

Deep Pocket Exploration

By | February 1, 2017

A modification to traditional docking software enables the examination of a ligand’s passage into its receptor.

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image: Infographic: Modeling Molecules’ Receptor Binding

Infographic: Modeling Molecules’ Receptor Binding

By | February 1, 2017

A software upgrade follows ligands step-wise into their binding sites on receptors.

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A test tube-based genome-labeling technique has been brought under the microscope.

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image: Top Technical Advances 2016

Top Technical Advances 2016

By | December 15, 2016

The year’s most impressive achievements include methods to watch translation in cells, trace cell fates, avoid mitochondrial mutations, edit DNA, and build antibiotics from scratch.

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image: Synthetic Sensors

Synthetic Sensors

By | December 1, 2016

Engineered circuits detect endogenous transcription factors to drive cellular outputs.

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image: Infographic: How to Build a Synthetic Sensor

Infographic: How to Build a Synthetic Sensor

By | December 1, 2016

Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.

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image: Neural Connectome Method Uses mRNA Barcodes

Neural Connectome Method Uses mRNA Barcodes

By | November 1, 2016

Researchers swap microscopy for RNA sequencing to track neural paths in the mouse brain.  

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image: Genetic Tags Illuminate Where Neurons Extend

Genetic Tags Illuminate Where Neurons Extend

By | November 1, 2016

Barcodes of mRNA travel to the cells' axon terminals, offering a sequencing-based approach to neural mapping.

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