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tag acute lymphoblastic leukemia culture

3D medical illustration showing acute lymphoblastic leukemia cells and red blood cells in circulation.
Niche Interactions Lock Down Leukemia Cells
Deanna MacNeil, PhD | Sep 24, 2023 | 3 min read
Researchers unravel the mystery of epithelial to mesenchymal transition in acute lymphoblastic leukemia with co-culture techniques, CRISPR-screening, and RNA sequencing.
A full blood sample vial lying on top of a piece of paper that reads “Acute lymphoblastic leukemia”.
Targeting Leukemia with T Cells That Avoid Self-Destruction
Deanna MacNeil, PhD | Sep 26, 2022 | 3 min read
Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena, PhD | Mar 5, 2021 | 4 min read
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
The Breakthrough Prize ?Trophy
2024 Breakthrough Prizes in Life Sciences
Danielle Gerhard, PhD | Sep 14, 2023 | 10 min read
This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.
car t chimeric antigen receptor t cell immunotherapy pyroptosis cell death perforin macrophage leukemia lymphoma
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Kerry Grens | Jan 20, 2020 | 2 min read
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Commander of an Immune Flotilla
Jef Akst | Apr 1, 2014 | 9 min read
With much of his early career dictated by US Navy interests, Carl June drew inspiration from malaria, bone marrow transplantation, and HIV in his roundabout path to a breakthrough in cancer immunotherapy.
DNA Chips Enlist in War on Cancer
Douglas Steinberg | Feb 20, 2000 | 10+ min read
Graphic: Cathleen Heard The boy had the classic symptoms of acute leukemia--low blood counts and tumor cells circulating in his bloodstream. But the diagnosis was tentative because the tumor cells looked atypical for leukemia. So doctors extracted RNA from the cells, made cDNAs from the RNA, and incubated the cDNAs with a chip bearing thousands of single-stranded gene fragments on its glass surface. The hybridization pattern suggested, surprisingly, that the boy had a muscle tumor. After confirm
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
decade 2019 2020 chimeras crispr neanderthal denisovan genome sequence ancient dna
What A Long, Strange Decade It’s Been
Bob Grant | Dec 20, 2019 | 5 min read
For the past 10 years, life science has moved us closer to a complete understanding of what makes us human—our similarities, our differences, and our shared history.
Opinion: How HIV Became Positive
JJ More | Sep 17, 2013 | 3 min read
Immunotherapies, such as the re-engineered T cells that last year saved a 7-year-old girl’s life, continue to show promise as cancer treatments.

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