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tag acute lymphoblastic leukemia cell molecular biology

3D medical illustration showing acute lymphoblastic leukemia cells and red blood cells in circulation.
Niche Interactions Lock Down Leukemia Cells
Deanna MacNeil, PhD | Sep 24, 2023 | 3 min read
Researchers unravel the mystery of epithelial to mesenchymal transition in acute lymphoblastic leukemia with co-culture techniques, CRISPR-screening, and RNA sequencing.
Molecular Biology
The Scientist Staff | Oct 11, 1992 | 2 min read
A. Kakizuka, W.H. Miller, K. Umesono, R.P. Warrell, et al., "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR with a novel putative transcription factor, PML," Cell, 66:663-74, 1991. Akira Kakizuka (The Salk Institute, La Jolla, Calif.): "Our paper described the genes located at each of the breakpoints of the t(15;17) translocation associated with human acute promyelocytic leukemia (APL). In addition to the karyotype abnormality, the patients with APL can be i
The MLL leukemia
Tudor Toma(t.toma@ic.ac.uk) | Dec 4, 2001 | 1 min read
Acute lymphoblastic leukemia with mixed-lineage leukemia gene (MLL) translocations has a particularly poor prognosis, but it is not clear if host-related factors or tumor-intrinsic biological differences are responsible for these poor survival rates. In December 3 on line Nature Genetics, Scott Armstrong and colleagues from Dana-Farber Cancer Institute, Boston, Massachusetts, show that acute leukemia with MLL translocations has a gene expression profile that identifies them as a unique, new type
Molecular Biology
The Scientist Staff | Mar 1, 1992 | 2 min read
M.P. Kamps, C. Murre, X.-h. Sun, D. Baltimore, "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in Pre-B ALL," Cell, 60:547- 55, 1990. Mark Kamps (University of California, San Diego): "In man, most chromosomal translocations elicit tumorigenic effects by introducing a strong enhancer adjacent to a normal cellular gene, such as c-MYC, and constitutively activating its expression. Less frequently, a chimeric oncogene forms by the joining of two distinc
Genotoxic Effects of Base and Prime Editing
Kamal Nahas, PhD | Jan 12, 2024 | 5 min read
A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 
Leukemia and Cancer Stem Cells
Irving Weissman and Michael Clarke | Apr 1, 2006 | 4 min read
FEATUREThe Ecology of Tumors Leukemia and Cancer Stem Cells BY IRVING WEISSMAN AND MICHAEL CLARKECancers and normal tissue stem cells have much in common: Both have self-renewal capacity, and both develop into differentiated progeny. But do true cancer stem cells exist? We believe that they do and that this realization will have a major impact on the understanding and treatment of cancers. Putative cancer stem cells can be recognized by three attr
New drug target for cancer
Katherine Bagley | Nov 10, 2009 | 3 min read
Scientists have developed a new drug that blocks a transcription factor -- previously thought to be un-blockable -- that has been causally linked to leukemia and several other cancers of the lungs, ovaries, pancreas, and gastrointestinal tract, they report in linkurl:Nature;http://www.nature.com/nature/index.html this week. Bone marrow smear showing acute lymphoblastic leukemia Image: Furfur, Wikimedia Commons The Notch transcription factor regulates cell-cell communication in the Notch signal
Scientists Successfully Transplant Human Leukemia Cells into Mice
Diana Kwon | Apr 1, 2017 | 2 min read
While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals.
Tumor-Targeting T Cells Engineered
Chris Palmer | Aug 11, 2013 | 3 min read
Scientists genetically modify T cells derived from pluripotent stem cells to attack lymphatic tumors.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.

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