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image: Secrets of Aging

Secrets of Aging

By | September 1, 2011

What does a normally aging brain look like? Are diseases of aging such as Alzheimer’s inevitable?

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image: What Causes Alzheimer’s?

What Causes Alzheimer’s?

By | September 1, 2011

Researchers and pharma companies have tried to attack this disease by reducing amyloid plaques, but inflammation may be the real culprit.

39 Comments

image: The Seat of Memory

The Seat of Memory

By | September 1, 2011

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.

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Contributors

September 1, 2011

Meet some of the people featured in the September 2011 issue of The Scientist.

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image: Hold That Thought

Hold That Thought

By | September 1, 2011

In the memory circuits of the aging brain and the signaling pathways of pain, science is trading mystery for mastery.

15 Comments

image: The Cytokine Cycle

The Cytokine Cycle

By | September 1, 2011

The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—microglia and astrocytes-- promoting them to produce IL-1 and S100 inflammatory cytokines.

12 Comments

image: Blood’s Role in the Aging Brain

Blood’s Role in the Aging Brain

By | August 31, 2011

A blood protein involved in allergy contributes to the decline in brain function and memory in aging mice.

18 Comments

image: Alzheimer’s Mice Still Available

Alzheimer’s Mice Still Available

By | August 17, 2011

Dropped from a patent lawsuit, at least one lab will be allowed to continue research on mouse models of Alzheimer’s disease.

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image: Memory Aid

Memory Aid

By | August 1, 2011

Editor's Choice in Neuroscience

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image: Down Syndrome brains look like Alzheimer’s

Down Syndrome brains look like Alzheimer’s

By | June 17, 2011

Comparable levels of protein buildup in the brains of Alzheimer's and Down Syndrome patients may explain the similarities in dementia seen in the two conditions.

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