imaging, neuroscience

Synaptic connections and a new neuron type emerge in high-res images, which hold promise for mapping the complete connectome.

A double-expansion technique embeds brain tissue in the absorbent material of diapers to stretch out cells for easier visualization.

The brain’s structural connections are unique to an individual, a new imaging technique reveals.

In the 1990s, the development of this gentler and more precise microscopy method improved scientists’ ability to probe neurons’ activity and anatomy.

Imaging and manipulating the brain has come a long way from electrodes and the patch clamp, though such traditional tools remain essential.

“Ultimate DISCO” uses a solvent that shrinks whole animals and preserves fluorescence for months.

The Scientist’s choice of major improvements in imaging, optogenetics, single-cell analyses, and CRISPR

Camillo Golgi’s black reaction revealed, for the first time, the fine structures of intact neurons, which he captured with ink and paper.

Researchers visualize the complete nervous system of a Drosophila melanogaster larva at nearly single-neuron resolution.

Researchers record the first whole-brain videos of an unrestrained animal, viewing neural activity as a roundworm moved freely around a Petri dish.

An inspiring lecturer turned Marcus Raichle’s focus from music and history to science. Since then, he has pioneered the use of imaging to study how our brains function.

Scientist to Watch, Takaki Komiyama, discusses his use of chronic two-photon calcium imaging to explore how wakefulness and experience shape odor representations in the mouse olfactory bulb.

Researchers image the electrical impulses of the C. elegans and zebrafish nervous systems.

Researchers offer a freely available map of the connections throughout the mouse cortex.  

The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.

Light microscopy techniques that spotlight neural connections in the brain

Karl Deisseroth and his team at Stanford University make mouse brains transparent to explore their inner workings.

Travel through the outer layers of a mouse brain thanks to array tomography and Stanford University's Stephen Smith.

An illustration depicting the damaging effects of a tumor (red) on structural connections within the brain

Researchers package a fluorescence microscope—including the light and camera—that can image the brain of a freely moving mouse.