Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.

Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.

Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.

Antigen-specific T lymphocytes must be quantified in order to gauge the quality of an immune response. Typically this is accomplished using cytotoxicity assays or limiting dilution analysis (LDA), but these techniques are lengthy and provide indirect quantitation. Also, LDA cannot count nonproliferative cells. In 1996, Stanford University's Mark Davis developed an alternative strategy that overcomes these problems.1 Davis generated phycoerythrin-conjugated tetramers of human lymphocyte antigen (

Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.

Beyond The Scientist’s coverage of COVID-19’s molecular underpinnings were many other stories highlighting the advances made in scientists’ understanding of the biology of cells.

Microbes in the gut influence the death of support cells in the brain by producing isoamylamine, a study suggests.