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tag nmr disease medicine

Collage of those featured in the article
Remembering Those We Lost in 2021
Lisa Winter | Dec 23, 2021 | 5 min read
As the year draws to a close, we look back on researchers we bid farewell to, and the contributions they made to their respective fields.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
The Chemistry of Attraction
Michelle Vettese-dadey | Mar 5, 2000 | 6 min read
Chemokines and their receptors help direct cell migration to sites of inflammation. You heard it here--chemokine receptors and ligands are in. Inflammation, cancer, asthma, rheumatoid arthritis, angiogenesis, and AIDS are just a few areas in which chemokines and their receptors are crucial. Therefore, chemokine pathways represent potentially valuable therapeutic targets. Asthma, one of the most common chronic diseases in the industrialized world, is recognized as an inflammatory disease, and ste
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin

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