cell & molecular biology, genetics & genomics

A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.

Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

Viruses that infect plants and occasionally insects appear to cause infection with a divide-and-conquer strategy, multiplying separate segments of genetic material in different host cells.

A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.

Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.

A study on yeast illuminates how insertions may occur.

This could account for some reproducibility problems in cell line research, according to the authors of a comprehensive analysis of HeLa variants.

Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.

Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.

The recent discovery of 17 people who have inherited maternal and paternal lines of mitochondrial DNA has major ramifications for medical and ancestry research.

In kidney organoids, brain and muscle cells also develop.

A pair of mouse studies describes neuronal subpopulations not identified before and some of their functions.

From journeys into mines to explorations of volcanoes on the ocean floor, deep voyages reveal the richness of the planet’s deep biosphere.

The genome of Ulva mutabilis is the first of a green seaweed to be sequenced.

A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.

Researchers have flagged several issues with so-called SmartFlares over the years, and it’s still unclear why they don’t appear to work under certain circumstances.

A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.

The cell type was discovered via single-cell RNA sequencing of thousands of cells in mouse and human airways and may play a role in cystic fibrosis.

Scientists at the Allen Institute for Cell Science have developed an open-source stem cell line with fluorescent tags for cardiac cells.