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Interrogating the Complexities of the Tumor Microenvironment
Interrogating the Complexities of the Tumor Microenvironment
Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.
Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.
RNA-seq
Unbalanced Allele Expression Associated with Mutation, Disease
Natalia Mesa, PhD | Feb 2, 2023 | 5 min read
A study identifies nearly 3,000 genes where one allele tends to be expressed more than the other, but the findings ignited controversy in the field.
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests.
The Scientist's Journal Club: Transcriptomics
The Scientist | 2 min read
Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.
Stem Cells in Human Teeth Follow the Rules of Their Environment
Roni Dengler, PhD | Feb 7, 2022 | 2 min read
How stem cells in human teeth respond to different environmental conditions offers clues for regenerative medicine.
Technical Bias Widespread in RNA-Seq Datasets
Diana Kwon | Nov 21, 2019 | 3 min read
Genes that are exceptionally long or short are overrepresented in some published reports, which can lead to misinterpreted results.
The Scientist’s Journal Club: Neuroscience
The Scientist | 1 min read
Scientists present the latest research on cortical neuronal networks, neuronal signaling, and amyloid-forming proteins.
Scientists Continue to Use Outdated Methods
Catherine Offord | Jan 8, 2018 | 7 min read
The use of underperforming computational tools is a major offender in science’s reproducibility crisis—and there’s growing momentum to avoid it.
Characterizing the Imprintome
Amber Dance | Jan 1, 2017 | 8 min read
Three techniques for identifying the collection of maternal and paternal genes silenced in offspring
The Scientist Speaks - What Comes Up Must Go Down: Maintaining Hormone Balance Through RNA Decay
The Scientist | 1 min read
Neelanjan Mukherjee discusses how RNA decay is essential for regulating a blood pressure-controlling hormone.
Scaling to Singles
Kelly Rae Chi | May 1, 2016 | 9 min read
Tips for tracing transcription in individual cells
Sperm RNAs Transmit Stress
Kate Yandell | Oct 19, 2015 | 3 min read
Stressed male mice can pass on an abnormal stress response to their offspring via microRNAs found in sperm, a study shows.
Fast Amplification-Based NGS Library Preparation
The Scientist | 1 min read
In this webinar, Jennifer Silverman and Kan Saito will discuss using rapid genome and transcriptome amplification kits on low input samples for next-generation sequencing.
Genetic Repression Boosts Memory
Kate Yandell | Oct 1, 2015 | 3 min read
Expression or translation of some genes must be turned off in the mouse hippocampus for memories to form.
An Array of Options
Kate Yandell | Jun 1, 2015 | 9 min read
A guide for how and when to transition from the microarray to RNA-seq
Biosurveillance for Viral Infections
The Scientist and Tecan | 1 min read
Scientists use ELISAs to assess the immunity and etiology of immune responses to coronavirus during the COVID-19 pandemic.
Circadian Atlas Chronicles Gene Expression
Kate Yandell | Oct 27, 2014 | 3 min read
Researchers have mapped the times of day when mouse genes are transcribed across 12 organs.
Cancer-Associated Viruses Overblown?
Tracy Vence | Aug 7, 2013 | 1 min read
An MD Anderson study calls into question estimates on the percentage of viruses linked to cancer.
Advances in Nucleic Acid Sequencing
The Scientist | 1 min read
Download this eBook to learn how new sequencing methods revolutionize genetics research!
Transcriptomics for the Animal Kingdom
Amy Maxmen | Jul 1, 2013 | 7 min read
Using RNA-seq to study nonmodel organisms