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tag bioinformatics developmental biology

Bioinformatics, Genomics, and Proteomics
Christopher Smith | Nov 26, 2000 | 10+ min read
Data Mining Software for Genomics, Proteomics and Expression Data (Part 1) Data Mining Software for Genomics, Proteomics and Expression Data (Part 2) High-throughput (HT) sequencing, microarray screening and protein expression profiling technologies drive discovery efforts in today's genomics and proteomics laboratories. These tools allow researchers to generate massive amounts of data, at a rate orders of magnitude greater than scientists ever anticipated. Initiatives to sequence entire genom
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018 | 7 min read
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
How to Track Cell Lineages As They Develop
Kelly Rae Chi | Dec 1, 2016 | 7 min read
Sequencing and gene-editing advances make tracing a cells journey throughout development easier than ever.
On the Fast Track in Functional Proteomics
A. J. S. Rayl | Apr 1, 2001 | 8 min read
Graphic: Leza Berardone Researchers in Canada and Denmark are employing mass spectrometry, three-dimensional tissue biology, and supercomputing to blaze a trail in functional proteomics research. In the process, they're putting their company, MDS Proteomics Inc., on the fast track in the latest race to develop new drug targets and eventually better treatments for all kinds of diseases. By using this combination of technologies, MDS Proteomics is accelerating the process of identifying, analyzin
The Genetics of Society
Claire Asher and Seirian Sumner | Jan 1, 2015 | 10 min read
Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.
Pushing Proteomics
Jim Kling | Apr 14, 2002 | 4 min read
Genomics is slowly but surely moving off center stage, replaced by proteomics. Though proteomics is a young field that hasn't fully found its stride, two new developments provide glimpses of the future. At the end of February, attendees of the Cambridge Healthtech Institute (CHI) Genome Tri-Conference 2002 in Santa Clara, Calif., got their first glimpse of the Protein Atlas of the Human Genome™. Developed by Abingdon, UK-based Confirmant Ltd.—a joint venture of Abingdon, UK-based Ox
Notable
Jeffrey Perkel | Jun 9, 2002 | 3 min read
Z. Mourelatos et al., "miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs," Genes & Development, 16[6]:720-8, March 15, 2002. "A novel ribonucleoprotein (RNP) complex in HeLa cells was identified that contains two proteins implicated in spinal muscular atrophy (SMA), eIF2C2 (a member of the Argonaute family), and numerous small RNAs ~22 nucleotides in length. The finding that microRNAs (miRNAs) associate with eIF2C2 ties together genetic findings demonstrating that Argona
Notable
Jeffrey Perkel | Jan 6, 2002 | 4 min read
J.A. Camarero et al., "Peptide chemical ligation inside living cells: In vivo generation of a circular protein domain," Bioorganic and Medicinal Chemistry, 9[9]:2479-84, September 2001. F1000 Rating: Recommended "To investigate whether chemo-selective peptide ligations work in vivo, the authors demonstrate the in vivo head-to-tail cyclization of a bioactive SH3 domain using native chemical ligation. The protein precursor was constructed using a clever combination of an intein-fusion protein an
When the Lights Went On for COP
Eugene Russo | Feb 15, 2004 | 5 min read
EYE CANDY:Courtesy of Greg Suh, University of California Los Angeles, Andrew Moore, InfrancoMoore GroupThis developing eye from a chimeric Drosophila has wild-type tissue at the top and csn5 mutant tissue at the bottom causing disorganization. Overlaid is a schematic showing the predicted metalloprotease site of CSN5 cleaving an isopeptide bond.It doesn't take a green thumb to predict what happens to plants left in the dark: They wither. But in the late 1980s and early 1990s, researchers, includ

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