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tag cloning evolution

bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Targeted Comparative Sequencing Illuminates Vertebrate Evolution
Ricki Lewis | Dec 8, 2002 | 6 min read
Image: Courtesy of Elliott Marguiles  PIPS ON PARADE: Researchers used a MultiPipMaker to show the alignments, expressed as percent identity plots, between a human reference sequence and several other species. This is a 20 kb region surrounding exon 2 of the MET gene. Gap-free alignable segments are represented as horizontal lines along the human reference sequence; the line's height represents the identity of that alignment. Aristotle envisioned humanity as the pinnacle of a "Great Chai
Checking the Alignment
Jane Salodof Macneil | Sep 21, 2003 | 9 min read
Courtesy of European Bioinformatics Institute  KNOWLEDGE GAPS? Sequence alignments offer clues to both the function and evolution of novel genes. But a bewildering array of algorithms and parameters leaves many researchers unable to use these programs to their fullest potential. In the beginning, there was Needleman-Wunsch, which begat Smith-Waterman, which begat FASTA, which begat BLAST, and so on. Peel away the information technology jargon surrounding these alignment algorithms, and a
2018 Top 10 Innovations
The Scientist | Dec 1, 2018 | 10+ min read
Biology happens on many levels, from ecosystems to electron transport chains. These tools may help spur discoveries at all of life's scales.
Capsule Reviews
Annie Gottlieb | Mar 1, 2013 | 3 min read
The Undead, Frankenstein's Cat, The Universe Within, and Physics in Mind
It’s Easy Being Green
Richard P. Grant | Jan 1, 2012 | 2 min read
Now RNA can glow in the cell, as only proteins could in the past.
Creative Emulsification
Sabrina Richards | Nov 1, 2012 | 8 min read
Enhancing data collection from emulsion PCR reactions: three case studies
Automated Colony Pickers Evolve
Helen Dell(hdell@the-scientist.com) | Jul 3, 2005 | 6 min read
Everyone knows that the first genome sequencing projects took years of work and represent the combined product of tens of thousands of individual fragments.
The Biggest Stories in Bioscience 2005
Ishani Ganguli | Dec 4, 2005 | 8 min read
Life scientists have been challenged more than ever this year not just to critically analyze data, but to better interpret those data for an increasingly critical public.
Mapping Subtelomeres
Ricki Lewis | Oct 14, 2001 | 4 min read
In genetics, certain terms sometimes mask what scientists do not yet understand, such as "junk DNA." Similarly, the chromosomal regions just proximal to the tips--the subtelomeres--have been dubbed "buffers," ill-defined DNA sequences that somehow support the telomeres, which control the cell cycle and cellular aging. A team of researchers from the Wistar Institute in Philadelphia, the University of California, Irvine, and John Radcliffe Hospital in Oxford, UK, has used single-copy sequences in

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