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The image shows four different bones with varying degrees of osteoporosis.
A Molecular Switch for Bone Loss
Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 
A Molecular Switch for Bone Loss
A Molecular Switch for Bone Loss

Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 

Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 

bone

fluorescently labeled microscopy cross-section of bone
Cancer Cells in Mice May Hitch a Ride with Bone-Healing Stem Cells
Andy Carstens | Nov 7, 2022 | 4 min read
Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types. 
A rooster crowing in a tree
Domesticated Chickens Were Initially Friends, Not Food
Amanda Heidt | Jun 7, 2022 | 4 min read
Analyses of bones found across the world suggest that the birds entered human settlements more recently than previously thought. But they don’t seem to have immediately made their way to the table, raising questions as to why people started keeping them.
The MSC: Regeneration Orchestrator
The Scientist Staff | 7 min read
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
Homing Technology Delivers Therapy to Cancerous Bone
Roni Dengler, PhD | Jul 19, 2021 | 5 min read
A clever approach to modifying already existing cancer therapies may be a game changer for treating metastatic breast cancer.
bone marrow exercise mouse osteolectin growth factor mechanical forces progenitors running exercise
Impact of Running Reaches Marrow to Spark Bone Growth in Mice
Emma Yasinski | Mar 2, 2021 | 3 min read
A study offers a new explanation for how exercise strengthens bones and the immune system.
Luis Alvarez Aims to Heal Wounds with Tissue-Regenerating “Paint”
Shawna Williams | Jul 13, 2020 | 3 min read
The bioactive coating tethers restorative proteins to implanted tissues and fosters new growth, animal studies suggest.
Two Studies Question Function of Bone Hormone Osteocalcin
Ruth Williams | May 29, 2020 | 4 min read
Independently produced knockout mouse strains fail to find evidence of the bone protein’s endocrine functions, and divide researchers’ opinions.
Image of the Day: Protodogs
Amy Schleunes | Mar 4, 2020 | 2 min read
An analysis of microwear patterns in fossilized canid teeth supports the theory that early dogs and wolves had distinct diets.
Image of the Day: Foot Biomechanics
Amy Schleunes | Mar 2, 2020 | 1 min read
A new study highlights the importance of the transverse arch in regulating the stiffness of the human foot.
New Discoveries in Human Anatomy
Diana Kwon | Feb 18, 2020 | 4 min read
Using advanced microscopy and imaging techniques, scientists have revealed new parts of the human body and overturned previous misconceptions.
Infographic: The Modern Human Body
Diana Kwon | Feb 18, 2020 | 1 min read
The last few years have yielded new insights into human anatomy. Explore this interactive graphic to learn about some of these discoveries.  
arthritis in rats
Image of the Day: Reversing Arthritis
Amy Schleunes | Jan 28, 2020 | 1 min read
A combination of two drugs appears to restore cartilage in rats.
Bone Hormone Sparks Fight-or-Flight Response in Mice
Ruth Williams | Sep 12, 2019 | 3 min read
A brain-activated, bone-derived hormone called osteocalcin regulates the acute stress response in rodents and possibly humans.
A. anamensis Hominin Skull Could Recast Our Human Family Tree
Ashley Yeager | Aug 28, 2019 | 2 min read
Researchers say the skull belongs to an Australopithecus species once thought to be a predecessor to “Lucy,” but now that relationship is murky.
bone microbiome inflammation wnt10b rankl
Bone and the Microbiome Have a Brittle Relationship
Kerry Grens | Jul 12, 2019 | 6 min read
Animal studies and a few small clinical trials show it’s possible to get commensal microbes to protect against bone loss, rather than contribute to it.
European eel Anguilla bone restructuring reabsorption rebuilding juvenile mature artificial maturation
Image of the Day: Internal Restructuring
Chia-Yi Hou | May 20, 2019 | 1 min read
Juvenile eels break down bone tissue and rebuild it in preparation for mating.
Tiny Knee Bone, Once Lost in Humans, Is Making a Comeback
Jef Akst | Apr 19, 2019 | 2 min read
The fabella disappeared from our lineage millions of years ago, but over the last century, its presence in people’s knees has become more common.
Researchers Identify Irisin’s Receptor in Bone and Fat
Carolyn Wilke | Dec 13, 2018 | 3 min read
They hope to develop the “exercise hormone” into therapeutics that harness the benefits of exercise for people unable to do so.
Human Skeletal Stem Cell Found
Abby Olena, PhD | Sep 20, 2018 | 3 min read
Researchers recovered the cells that give rise to bone and cartilage from fetal and adult bone marrow and also derived them from induced pluripotent stem cells.
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