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tag autoimmune disease microbiology developmental biology neuroscience

Artist’s rendition of a neuron silhouetted against a glowing red background.
SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s
Dan Robitzski | Jan 6, 2023 | 4 min read
Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox, PhD | Sep 12, 2022 | 10+ min read
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.
Top 7 papers in neuroscience
Megan Scudellari | Oct 11, 2010 | 3 min read
A snapshot of the highest-F1000-ranked articles in neuroscience and related areas
The Role of Mom’s Microbes During Pregnancy
Carolyn A. Thomson and Kathy D. McCoy | Aug 1, 2021 | 10+ min read
Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
The Sum of Our Parts
Janice Dietert and Rodney Dietert | Jul 1, 2015 | 10+ min read
Putting the microbiome front and center in health care, in preventive strategies, and in health-risk assessments could stem the epidemic of noncommunicable diseases.
Those We Lost in 2019
Ashley Yeager | Dec 30, 2019 | 6 min read
The scientific community said goodbye to Sydney Brenner, Paul Greengard, Patricia Bath, and a number of other leading researchers this year.
Brainstorms Abound At NIH's Neurological And Stroke Institute
Neeraja Sankaran | Mar 19, 1995 | 8 min read
Research in the neurosciences is in the midst of a particularly exciting period of discovery, says Zach Hall, director of the National Institute of Neurological Disorders and Stroke (NINDS), as scientists continue to learn more about the basic biology of such disorders as stroke, epilepsy, and degenerative conditions like Parkinson's, Alzheimer's, and Huntington's diseases. Hall's institute has supported and participated in many of these landmark studies. Now the field stands poised on the brin
Strep and Obsessive-Compulsive Disorder: What's the Link?
Harvey Black | Sep 12, 1999 | 6 min read
For about a decade, Susan Swedo, chief of the Pediatric and Developmental Neuropsychiatry Branch of the National Institute of Mental Health (NIMH), has been investigating how an ordinary strep infection can trigger an autoimmune response leading to obsessive-compulsive disorder (OCD). She, her colleagues at NIMH, and other researchers have been exploring this link with a goal of better understanding the role of the brain in mental disorders and developing better OCD treatments. Though strep is

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