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tag autism neuroscience

Histology showing IL-6 expression
Immune Molecule Alters Cellular Makeup of Human Brain Organoids
Charles Q. Choi, Spectrum | Apr 17, 2023 | 4 min read
The changes may help explain the link between maternal infection and autism, though more research is needed.
Histology of brain
Rare Autism-Linked Mutation Starves Growing Neurons of Essential Nutrients
Lauren Schenkman, Spectrum | Apr 18, 2023 | 4 min read
The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.
A mutated cell with a spiky membrane
Mutations in Autism-Linked Gene Cause Membrane Mischief
Holly Barker, PhD, Spectrum | Jan 26, 2023 | 4 min read
Inactivating TAOK1 prompts tentacle-like protrusions to form all over a neuron’s surface, revealing the gene’s role in molding the membrane.
Coronal section of a brain
Immunity-Linked Genes Expressed Differently in Brains of Autistic People
Laura Dattaro, Spectrum | Jan 11, 2023 | 4 min read
Data from postmortem brain tissues adds to the evidence that inflammation is associated with autism.
Panels showing different kinds of microglia
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets
Angie Voyles Askham, Spectrum | Dec 14, 2022 | 4 min read
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
pregnant belly clad in hospital gown with IV line going into hand
Registry Review Casts Doubt on Causal Link Between Maternal Infection and Autism
Charles Q. Choi, Spectrum | Sep 26, 2022 | 4 min read
Maternal infection during pregnancy may be associated with autism, as previous studies have suggested—but perhaps not in a causal way.
A pregnant woman gets her blood pressure checked by a doctor
U.K. Health Authority Investigates Epilepsy Drug’s Link to Autism
Peter Hess, Spectrum | Aug 30, 2022 | 3 min read
The Medicines and Healthcare products Regulatory Agency’s investigation comes after a study showed prenatal exposure to topiramate roughly triples a child’s likelihood of having autism or intellectual disability.
Microscopy image showing patches of magenta and green
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
Angie Voyles Askham, Spectrum | Feb 3, 2022 | 3 min read
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.
illustration of neurons in blue with synapses lighting up
Gut Molecule Linked to Decreased Myelination in Mouse Brains
Angie Voyles Askham, Spectrum | Feb 17, 2022 | 4 min read
A study shows that a molecule produced by intestinal microbes can enter the brain and that its presence is also associated with altered brain connectivity.
SYNGAP1 helps neurons eliminate old synapses and form new ones after a novel experience (left and center left)—a process weakened in mice missing a copy of the gene (center right and right).
Autism-Linked Gene SYNGAP1 Molds Synaptic Plasticity, Learning
Angie Voyles Askham, Spectrum | Oct 26, 2021 | 4 min read
The finding may help to explain why people with SYNGAP1 mutations tend to have learning difficulties and a high tolerance for pain.

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