Philippa “Pippa” Marrack has made some unanticipated discoveries about how the immune system functions in health and disease.
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Looking for a more realistic way to study memory, we turned to place cells—a network of cells that record a rat’s memory of an environment. Each place cell would fire only when the rat was in one particular location in space, creating a map as the
Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. Since many diseases of aging affect memory, could memory formation and storage be altered by the same mechanisms in normal aging and diseased
In the memory circuits of the aging brain and the signaling pathways of pain, science is trading mystery for mastery.
The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—from traumatic brain injury, to epilepsy, infection, or genetic predisposition—can activate brain immune cells—
A blood protein involved in allergy contributes to the decline in brain function and memory in aging mice.
Researchers identify an antibody profile that may mark patients who suffer persistent symptoms of the tick-borne disease.
The Nobel Prize winner who discovered the gene that encodes the major histocompatibility complex passes away at age 90.
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