Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39
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Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role
Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40
More than simply helping haul out a cell’s garbage, ubiquitin, with its panoply of chain lengths and shapes, marks and regulates many unrelated cellular processes.
Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. As a monomer, ubiquitin can bind and tag ot
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
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